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Enhancing Urban Connectivity and Regeneration of Historic Areas: Case Study of Heart of Sharjah
منشور في 2020"…The study yielded several significant findings; most notable was the increment of the integration value of the optimized master plan by approximately 41% in comparison with Shurooq proposed master plan 2025, as a result of improving the urban configuration, the street network enhances the connection between the old district and the waterfront, and introducing a central plaza to be connected with Al Rola park to achieve the holistic desired approach.…"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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A national study on nurses’ retention in healthcare facilities in underserved areas in Lebanon
منشور في 2013"…Such imbalances are often aggravated in underserved areas, especially in developing countries. Despite the centrality of this issue, there is a dearth of studies that examine the retention of nurses in underserved areas in the Middle East Region. …"
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A systematic review of Arabic text classification: areas, applications, and future directions
منشور في 2023"…The review concludes by proposing areas where further research is required, such as addressing the unbalanced dataset issue, enhancing the preprocessing phase, and exploring human factors’ role in utilizing ATC systems.…"
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The role of protected areas in modulating vegetation response to climatic stressors in hyper-arid ecosystems
منشور في 2025"…These results demonstrate that the establishment of protected areas in 2006 enhanced vegetation–climate coupling in hyper-arid ecosystems, particularly through improved responsiveness to moisture-related variables. …"
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Meta Reinforcement Learning for UAV-Assisted Energy Harvesting IoT Devices in Disaster-Affected Areas
منشور في 2024"…<p dir="ltr">Over the past decade, Unmanned Aerial Vehicles (UAVs) have attracted significant attention due to their potential applications in emergency-response applications, including wireless power transfer (WPT) and data collection from Internet of Things (IoT) devices in disaster-affected areas. …"
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Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis
منشور في 2019"…</p><h3>Objective</h3><p dir="ltr">Identification of the specific symptoms that most motivate individuals to seek treatment information may offer insights for further improving brief interventions. To this end, we used anonymized internet search engine data to investigate which medical conditions and symptoms preceded searches for 12-step meeting locators and general 12-step information.…"
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Taguchi Approach for Optimizing Carbonization Parameters of Tea Waste To Enhance Adsorptive Biochar Properties
منشور في 2026"…These results confirm that Taguchi-based optimization significantly enhances biochar properties such as surface area, thermal stability, and morphology. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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Nanomaterials in fire protection: Innovations for enhanced safety and durability
منشور في 2025"…Nanomaterials offer enhanced efficiency, long-term durability, and reduced environmental impact compared to traditional flame retardants. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"