Intratumoral FoxP3⁺Helios⁺ Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal Cancer حسب Azharuddin Sajid Syed Khaja (19720114)

"…Levels of CD4⁺FoxP3⁺Helios⁺ Tregs were significantly increased in the TME. …"

Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1⁺/NKX6.1⁺ progenitors حسب Noura Aldous (15429873)

"…</p><h3>Conclusions/interpretation</h3><p dir="ltr">These findings suggest that pancreatic hypoplasia and reduced islet cell formation associated with RFX6 mutations are not due to alterations in PDX1⁺/NKX6.1⁺ PPs but instead result from cellular apoptosis and downregulation of pancreatic endocrine genes.…"

FoxP3⁺ T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets حسب Reem Saleh (3513056)

"…We discuss the prognostic significance of FoxP3⁺ Tregs in different cancers and their potential use as prognostic biomarkers. …"

National Ambulance Service’s Preparation for the FIFA World Cup Qatar 2022^TM حسب Montaha Khaled Chakif (18505072)

Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications حسب Fang Yu (156838)

"…</p> <h2>Key points</h2> <ul> <li>A floxed stromal interaction molecule 1 (STIM1) hypomorph mouse model was generated with significant reduction in Ca²⁺ influx through store-operated Ca²⁺ entry (SOCE), resulting in defective nuclear translocation of nuclear factor of activated T cells, cytokine production and inflammatory response. …"

Airway surface liquid volume expansion induces rapid changes in amiloride-sensitive Na⁺transport across upper airway epithelium-Implications concerning the resolution of... حسب Fouad Azizi (11835843)

"…We previously demonstrated that elevation of submucosal hydrostatic pressure increases airway epithelium permeability resulting in ASLV expansion by 500 μL cm⁻² h⁻¹. …"

Increased Levels of Circulating and Tumor-Infiltrating Granulocytic Myeloid Cells in Colorectal Cancer Patients حسب Salman M. Toor (8854751)

"…Interestingly, the expansion of peripheral GMCs correlated with higher stage and histological grade of cancer, thereby suggesting their role in cancer progression. Furthermore, an increase in CD33⁺CD11b⁺HLA-DR⁻CD14⁻CD15⁻ immature myeloid cells was also observed in CRC tumor tissue. …"

Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation حسب Mahéva Vallet (18456729)

"…At 52 weeks, Oc.S/BS did not differ between genotypes but single labelled perimeter (SL.Pm/B.Pm (%)) was significantly higher in Rin3⁻/⁻ mice (24.4 ± 6.4 vs. 16.5 ± 3.8, p = 0.003). …"

Deep learning-based modeling of land use/land cover changes impact on land surface temperature in Greater Amman Municipality, Jordan (1980–2030) حسب Khaled F. Alkaraki (22051967)

"…The results of modeling LST showed an increase in average LST for all land cover types, with the most significant increases evident within urban areas and Rangelands/Sparsely vegetated areas. …"

The Immunophenotyping Changes of Peripheral CD4+ T Lymphocytes and Inflammatory Markers of Class III Obesity Subjects After Laparoscopic Gastric Sleeve Surgery – A Follow-Up Study... حسب Nasser M Rizk (18810328)

"…A significant reduction of plasma IL-6, TNF-α, and MCP-1, but IL-10 significantly increased after LGS, with all p< 0.05. …"

Immune Checkpoints in Circulating and Tumor-Infiltrating CD4+ T Cell Subsets in Colorectal Cancer Patients حسب Salman M. Toor (8854751)

"…We found a significant increase in the levels of CD4⁺FoxP3⁺Helios⁺ T cells, which represent potentially highly immunosuppressive Tregs, in the CRC TME. …"

Enhanced natural convection in a U-shaped baffled cavity: Synergistic effects of magnetic fields and wall oscillations on Nano-encapsulated PCM حسب Ahmed M. Hassan (8893106)

"…Results show that the Rayleigh number has the most significant impact, increasing the time-averaged Nusselt number by 129.8 % as <i>Ra</i> rises from 10³ to 10⁵. …"

Walking around the preferred speed: examination of metabolic, perceptual, spatiotemporal and stability parameters حسب Lina Majed (7485380)

"…While metabolic, perceptual and spatiotemporal values were sensitive to the smallest change in speed (i.e., 0.5 km·h⁻¹⁾, a significant increase in the rate of carbohydrate oxidation and decrease in % fat oxidation were only observed at speeds above PWS. …"

Identification of two HLA-A*0201 immunogenic epitopes of lactate dehydrogenase C (LDHC): potential novel targets for cancer immunotherapy حسب Remy Thomas (702843)

"…More specifically, we found an increase in IFN-γ secretion by CD8 + T cells and cancer-cell-killing of HLA-A*0201/LDHC positive breast cancer cells by LDHC⁴¹⁻⁵⁵- and LDHC^288−303-induced T cells, albeit with a possible antigen recognition threshold. …"

Postprandial lipaemia 10 and 34 hours after playing football: Does playing frequency affect the response? حسب Darren J. Paul (6905450)

"…They arrived to the laboratory 10 hrs and 34 hrs after the final football session and blood samples were collected at fasted (0 min) and 45, 90, 240 and 360 min post a high fat load meal. There were non significant increase for postprandial TG AUC (9.1%; p = 0.17; 95%CI = -0.43 to 2.0; ES = -0.23) and iAUC (14.2%; p = 0.43; 95%CI = -0.92 to 1.9; ES = -0.24) between 10 and 34 hrs after the 1FOOT. …"

Giving anaemic cardiac surgery patients a better chance حسب Nature Research (16552612)

"…A “liberal” group was to be given a blood transfusion if their haemoglobin levels fell below 9 milligrams per decilitre (mg dl­⁻¹). Doctors would wait longer, however, in the case of a “restrictive” group, which would be given a transfusion if their haemoglobin fell below 7.5 mg dl­⁻¹. …"

The effect of colchicine on myocardial infarction: An updated systematic review and meta-analysis of randomized controlled trials حسب Ayesha Younas (7114868)

"…Colchicine demonstrated statistically significant reduction in the composite of adverse cardiovascular events (RR = 0.75, 95 % CI: 0.60-0.94, P = 0.01, I² = 47 %), and hospitalization urgency (RR = 0.46, 95 % CI: 0.31-0.68, P = 0.0001, I² = 0 %) but statistically significant increment in adverse gastrointestinal events (RR = 1.86, 95 % CI: 1.14-3.02, P = 0.01, I² = 79 %). …"

Thermal regulation of algae cultures in raceway ponds utilizing ground heat: Improving techno-economic feasibility and process sustainability of large-scale algae production in Qat... حسب Rihab Rasheed (14153385)

"…<p dir="ltr">There is an increasing drive for developing sustainable alternatives for fuels, foods, feeds, and chemicals. …"

Co-production of high density biomass and high-value compounds via two-stage cultivation of Chlorella vulgaris using light intensity and a combination of salt stressors حسب Eman A. El-fayoumy (17788952)

"…Cultivation of C. vulgaris in a medium containing 7.5 g L⁻¹ NaCl/ 7.5 g L⁻¹ CaCl₂ had remarkably increased the lipid content (31.15 ± 1.18%) and lipid productivity (14.55 ± 1.48 mg L⁻¹ d⁻¹). …"

Synthesis and evaluation of novel Cu-based adsorbent-containing catalysts for CO₂ hydrogenation to methanol and value-added products حسب Rim Ismail (18192922)

"…The best performing catalyst was further promoted using 0.5 wt% Rh promoter which improved both methanol selectivity and space time yield to 23.2% and 0.08 g_MeOHg_cat⁻¹h⁻¹, respectively. The comparative high performance of the Rh-promoted catalyst was attributed to smaller metal oxide particle size with uniform dispersion, presence of effective hydrogen spill over, moderate basic sites, surface defects and presence of induced copper species.…"