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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Policy Brief: Addressing Barriers and Empowering Entrepreneurs in Lebanon.
منشور في 2025"…This policy brief examines the key factors influencing entrepreneurial success in Lebanon, focusing on gender dynamics, socio-cultural barriers, and systemic challenges. Entrepreneurship plays a critical role in Lebanon’s economic growth, innovation, and job creation, yet local entrepreneurs face significant obstacles. …"
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Barriers of Adopting Artificial Intelligence Tools in Engineering Construction Projects
منشور في 2023"…These issues may limit AI tool use or increase legal liability, hindering adoption. Integrating AI technology may be costly, especially for smaller companies with limited funds. …"
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Breast cancer screening in Lebanon: Understanding knowledge, attitudes and barriers
منشور في 2024"…Furthermore, 38.5 % encountered obstacles to mammography screening. Education significantly affected BC knowledge. Interestingly, increased knowledge of BC reduced barriers to mammographic screening. …"
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The Environmental Barriers to Active School Travel Among Private School Students in Dubai
منشور في 2021"…Among built environment features, street connectivity and traffic calming measures are significant factors. Since most of the private school students in Dubai are living beyond the walking distance threshold, it may be concluded that distance between home and school is the main barrier to AST.…"
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Policy Brief on Entrepreneurship in Lebanon Unlocking Potentials: Addressing Barriers and Empowering Entrepreneurs in Lebanon
منشور في 2024"…The socio-cultural context presents unique barriers for women entrepreneurs, who face gender norms and structural inequalities. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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Predictors, barriers, and facilitators to refugee women’s employment and economic inclusion: A mixed methods systematic review
منشور في 2024"…The qualitative synthesis uncovers three key themes: the meaning and significance of employment; barriers to employment; and facilitators and coping for employment. …"