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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Ethnic and gender differences in the use of DISCOVER
منشور في 2009"…Plots of the interaction showed that South Pacific/Pacific Islanders scored highest on Oral Linguistic whereas White Americans scored highest in Math and Native Americans scored highest in Spatial Artistic activity. No gender differences in identification were found. All ethnic groups were well represented among identified students, suggesting that DISCOVER might be used in different countries and with culturally diverse students…"
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Factors Influencing the Magnitude and Clinical Significance of Drug Interactions Between Azole Antifungals and Select Immunosuppressants
منشور في 2006"…By bringing similarities and differences among these agents and their potential interactions to clinicians’ attention, they can appreciate and apply these findings in a individualized patient approach rather than follow only the one-size-fits-all dosing recommendations suggested in many tertiary references. …"
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Ethnic and Gender Differences in Identifying Gifted Students
منشور في 2010"…Plots of the interaction showed that South Pacific/Pacific Islanders scored highest on Oral Linguistic whereas White Americans scored highest in Math and Native Americans scored highest in Spatial Artistic activity. No gender differences in identification were found. All ethnic groups were well represented among identified students, suggesting that DISCOVER might be used in different countries and with culturally diverse students.…"
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A Novel Steganography Technique for Digital Images Using the Least Significant Bit Substitution Method
منشور في 2022"…Therefore, the proposed work, in this paper, is based on the Least Significant Bit (LSB) substitution method. The LSB substitution method can minimize the error rate in embedding process and can achieve greater reliability in criteria, using novel algorithm based on value difference. …"
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Enhancing Arabic Reading Proficiency as a Second Language: Unveiling the Significance of Audiobooks for Middle School Students
منشور في 2024"…Eleven Arabic teachers from different Dubai schools participated in this qualitative study to determine the significance of audiobooks for non-native Arabic speakers enrolled in Dubai middle schools. …"
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Long-term antibiotic resistance surveillance of gram-negative pathogens suggests that temporal trends can be used as a resistance warning system
منشور في 2002"…The analysis of resistance levels and antibiotic consumption in the present study suggests different mechanisms for the increased resistance. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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Managers’ and employees’ differing responses to security approaches
منشور في 2017"…Modern organizations face significant information security threats, to which they respond with various managerial techniques. …"
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