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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Artisanal fishing of spiny lobsters with gillnets — A significant anthropic impact on tropical reef ecosystem
منشور في 2015"…The analysis of target species using nocturnal visual census demonstrated a significantly higher number of P. echinatus at the site where gillnet use was virtually absent within three sampled habitats, fringe, cave and soft bottom. …"
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Sustainable Consumption and Education for Sustainability in Higher Education
منشور في 2022"…Since its implementation in 2015, SC is an expanding area of research as the increased occurrence of environmental impacts is observed globally. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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A national study on nurses’ retention in healthcare facilities in underserved areas in Lebanon
منشور في 2013"…Rural nurses working in PHC centers were more satisfied than their hospital counterparts on all aspects of work and had significantly higher intention to stay (62.5% compared to 31.5% in hospitals, P < 0.001). …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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Dynamic Performance Investigation of Solar‐Driven Vapor Absorption Cooling System for Urban Areas
منشور في 2025"…<p dir="ltr">Solar energy in urban areas due to excessive air conditioning usage in buildings may significantly reduce the consumption of fossil fuels. …"
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Land surface temperature responses to land use dynamics in urban areas of Doha, Qatar
منشور في 2024"…Rapid urbanization primarily converts naturally vegetated areas and pervious surfaces into impervious built-up areas, significantly transforming microclimates and ecological dynamics. …"
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Land surface temperature responses to land use dynamics in urban areas of Doha, Qatar
منشور في 2024"…<p>Rapid urbanization primarily converts naturally vegetated areas and pervious surfaces into impervious built-up areas, significantly transforming microclimates and ecological dynamics. …"
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Vegetation communities and identification of indicator species in the riparian areas of Zabarwan mountain range in the Kashmir Himalaya
منشور في 2023"…Shannon Diversity was also found to be higher in communities 2 and 3, indicating that the vegetation there was more diverse. …"