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Recent advances in the treatment and outcome of locally advanced rectal cancer
منشور في 1999"…Background Preoperative therapy has been used in locally advanced rectal cancer to preserve sphincter function, decrease local recurrence, and improve survival. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Insights into rechargeable Zn-air batteries for future advancements in energy storing technology
منشور في 2023"…Therefore, this review provides significant insights into the fundamentals of Zn air battery system in terms of the underlying electrochemical mechanism, composition/structural performance relationship of different battery components. …"
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Provision of spiritual care to advanced cancer patients by doctors and nurses in the Middle East
منشور في 2016"…Background: In the US, ∼75% of advanced cancer patients want doctors and nurses to provide some spiritual care, and a similar percentage of staff believe they should do so. …"
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Advancements in radiative cooling structures for atmospheric water harvesting: A comprehensive review
منشور في 2025"…The study highlights significant potential for developing passive AWH technologies integrated with RC systems, demonstrating effectiveness across various geographical areas and climate conditions. …"
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Endocrine contribution to the sexual dysfunction in patients with advanced chronic kidney disease and the role of hyperprolactinemia
منشور في 2021"…Patients treated with cabergoline (<i>n</i> = 26) showed a significant increase in LH levels (<i>p</i> = .003) and a significant decrease in prolactin levels (<i>p</i> = .003). …"
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Advancing human and social dimensions in balanced scorecards for GCC corporations: a nuanced approach
منشور في 2024"…The findings highlight a significant gap between existing performance measurement frameworks and the demands of the contemporary business ethos, marked by the sociocultural nuances of the GCC. …"
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Extent and Mitigation of Financial Toxicity of Immune Checkpoint Inhibitors for the Treatment of Advanced Hepatocellular Carcinoma
منشور في 2025"…<p dir="ltr">Advanced hepatocellular carcinoma (HCC) is a serious condition associated with significant morbidity and mortality. …"
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Myeloid Cells in Circulation and Tumor Microenvironment of Colorectal Cancer Patients with Early and Advanced Disease Stages
منشور في 2020"…Lastly, we found that levels of GMCs decreased, while IMCs increased in the TME with tumor budding. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"