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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Factors Determining SMEs Intention to Access Alternative Financing in Emerging Markets: Evidence from the UAE
منشور في 2023"…The realm of alternative finance presents a valuable opportunity for SMEs in the UAE to address their funding gaps. …"
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Bank-Specific and Macroeconomic Determinants of Islamic Banks Profitability: The Case of GCC Countries
منشور في 2020"…The bank’s profitability is measured by the return on asset (ROA), whereas the independent variables that tested are capital adequacy ratio, operational efficiency, assets quality, financial leverage, bank size, liquidity risk, GDP growth, and inflation rate. The regression results indicate that bank-specific determinants including capital adequacy ratio, financial leverage, and operational efficiency are statistically significant and have negative relationship with the Islamic bank’s profitability. …"
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Exploring the bearing of liquidity risk in the Middle East and North Africa (MENA) banks
منشور في 2024"…The analysis employs Ordinary Least Squares (OLS) and panel regression techniques, including fixed and random effects models. …"
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Metabolomics-based prediction model for diabetes: A comprehensive analysis of biomarkers and machine learning approaches
منشور في 2025"…Correlation analysis identified 140 metabolites significantly associated with diabetes status (p < 0.05). …"
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The Impact of Non-Interest Income on Commercial Bank Profitability in the Middle East and North Africa (MENA) Region
منشور في 2024"…Non-interest income significantly influences the profitability of MENA region banks across all three models, supporting the main hypothesis. …"
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Regional variations in incidence of surgical site infection and associated risk factors in women undergoing cesarean section: A systematic review and Meta-Analysis
منشور في 2025"…Meta-regression showed a significant decrease in SSI incidence in HICs. …"
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Clinical and biochemical determinants of length of stay, readmission and recurrence in patients admitted with diabetic ketoacidosis
منشور في 2023"…Results from this study with a diverse population may be valuable for physicians and healthcare systems to decrease the diabetes-related healthcare burden in DKA patients.…"
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Correlations between Resting Electrocardiogram Findings and Disease Profiles: Insights from the Qatar Biobank Cohort
منشور في 2024"…Results: Significant associations were observed with ECG traits. …"
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Determinants of Off-Balance Sheet Business in the Case of GCC Banking Sectors during Covid-19
منشور في 2025احصل على النص الكامل
doctoralThesis