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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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Risk of post-ERCP pancreatitis with placement of self-expandable metallic stents
منشور في 2010"…When significant variables were added to a multiple-predictor regression model, the odds of PEP from SEMS placement increased to 6.8 (95% CI, 2.2, 21.4). …"
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Maternal and Neonatal Outcomes Post Bariatric Surgery: A Population-Based Study
منشور في 2023"…P value was regarded as significant at <0.05</p> <h3>Results</h3> <p>Qatari, advanced maternal age, Parity >1, diabetes, and hypertension were found to be significant risk factors for women with post-BS.…"
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Analyzing hydrodynamic changes in the Dubai Creek: a pre- and post-extension study
منشور في 2023احصل على النص الكامل
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Post‐Operative Analgesics Score, Another Tool in the Quest for a Better Pain Management
منشور في 2023"…This holds true especially in inguinal hernia surgery, an area where the confluence of three nerves and their surgical handling are associated with a significant incidence of debilitating chronic post-inguinal surgery pain (CPIP). …"
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Cardiovascular impact of post-traumatic stress disorder: A systematic review and meta-analysis
منشور في 2024"…<h3>Background</h3><p dir="ltr">Post-traumatic stress disorder (PTSD) is increasingly recognized for its effects beyond mental health, with emerging evidence suggesting a significant association with cardiovascular diseases (CVD). …"
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NMT verb rendering: A cognitive approach to informing Arabic-into-English post-editing
منشور في 2022"…<p>Machine translation (MT) has made significant strides and has reached accuracy levels that often make the post-editing (PE) of MT output a viable alternative to manual translation. …"
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Necrotizing Soft Tissue Infection Post VASER-Assisted Liposuction and Lipofilling: A Case Report
منشور في 2023"…The complication rate is very minimal, and it increases relatively when combined with other procedures. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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The Association Between Childhood Maltreatment and Post-Traumatic Stress Disorder (PTSD) Among Young Adults in Northern Syria
منشور في 2025"…Furthermore, exposure to emotional abuse in childhood significantly increased the probability of developing PTSD in adulthood (Odds ratio [OR], 0.7; 95% [CI], 0.5–0.9, <i>P</i> <.01). …"