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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Swimming exercise improves short‐ and long‐term memories: Time‐course changes
منشور في 2021"…Young adult Wistar rats were tested for both short-term and long-term memories using the radial arm water maize (RAWM) paradigm following 0, 1, 7, 14, and 28 days of swimming exercise training (60 min per day, 5 days/week)s. …"
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Supervised term-category feature weighting for improved text classification
منشور في 2022"…In this study, we provide a novel text classification framework for Category-based Feature Engineering titled CFE. It consists of a supervised weighting scheme defined based on a variant of the TF-ICF (Term Frequency-Inverse Category Frequency) model, embedded into three new lean classification approaches: (i) IterativeAdditive (flat), (ii) GradientDescentANN (1-layered), and (iii) FeedForwardANN (2-layered). …"
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A Diffusion-Based Probabilistic Ultra-Short-Term Solar Power Prediction Using the Sky Image Sequences
منشور في 2025"…Accurate ultra-short-term PhotoVoltaic (PV) power forecasting is crucial for the efficient and reliable operation of these energy systems. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
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Exploring clinical leadership in long‐term care: An integrative literature review
منشور في 2021"…All selected articles were quality appraised using the Critical Appraisal Skills Program and the accuracy, authority, coverage, objectivity, date and significance checklist.</p> <h3> Key Issues</h3> <p>The analysis resulted in four themes: ambiguous definitions, practice-based and value-driven care, the impact of clinical leadership and clinical leadership development for Canadian nurses.…"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A new tabu search algorithm for the long-term hydro scheduling problem
منشور في 2002"…The algorithm is based on using the short-term memory of the tabu search (TS) approach to solve the nonlinear optimization problem in continuous variables of the LTHSP. …"
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Dosing and Monitoring of Trace Elements in Long-Term Home Parenteral Nutrition Patients
منشور في 2011"…Conclusions: TE doses in home PN should be individualized and adjusted based on regular monitoring of TE status. In long-term home PN patients, higher zinc and selenium doses may be necessary to maintain their normal serum concentrations. …"
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Anomaly Detection on Smart Grids With Optimized Convolutional Long Short-Term Memory Model
منشور في 2025"…This study presents an approach for anomaly detection in smart grids through energy consumption readings from smart meters on the customer side using an optimized lightweight convolutional long short-term memory (ConvLSTM) model. This study benchmarks and evaluates different machine learning models against seven FDI attacks, which are multi-class labeled. …"
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Moderating Effects of Tourists’ Novelty-Seeking Tendencies on Destination Image, Visitor Satisfaction, and Short- and Long-Term Revisit Intentions
منشور في 2013"…The effect of destination image on visitor satisfaction, as well as satisfaction on short-term revisit intentions, is significantly weaker for high novelty seekers as compared to low novelty seekers. …"
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A geographic information system method to generate long term regional solar radiation resource maps: enhancing decision-making
منشور في 2024"…This study presents long-term solar resource monthly maps for Qatar. The availability of solar radiation throughout the country has been mapped here using ground-based measurements and satellite data. …"
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Adult Sexual Function Following Hypospadias Repair in Childhood: A Systematic Review and Meta-Analysis of Long-Term Patient Outcomes
منشور في 2025"…</p><h3>Methods</h3><p dir="ltr">A systematic review and meta-analysis were conducted based on PRISMA guidelines to assess long-term outcomes of hypospadias repair on adult sexual function. …"