A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity حسب Wesam S. Ahmed (10170053)

"…Further, analysis of trajectories for <u>hydrogen bonds</u> (H-bonds) formed between NLuc and furimazine revealed substantial H-bond interaction between R162 and Q32 residues. Mutation of the two residues in NLuc revealed a decreased but stable activity of the R162A, but not Q32A, mutant NLuc in live cell and in vitro assays performed using lysates prepared from cells expressing the proteins and with the furimazine substrate. …"

Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex حسب Wesam S. Ahmed (10170053)

"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. By elucidating a mechanistic basis for the increased affinity of the N501Y mutant S1-RBD for ACE2, we believe that the results presented here will aid in developing therapeutic strategies against SARS-CoV-2 including designing of therapeutic agents targeting the ACE2-S1-RBD interaction.…"

The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu... حسب Wesal Habbab (17346961)

"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"

The Effect of the Variation of the Modulus of Subgrade Reaction on the Design of Large Shallow Foundations حسب Al Kaaby Al Zoaby, Hassan

"…With the use of variable coefficient across the mat foundation, a significant decrease in the steel reinforcement is witnessed and an optimized/ more adapted steel distribution is observed.…"
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Optimization of Electric Vehicles Wireless Charging حسب Gesrou, Abdalla

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Modification of glucocorticoid effects on body weight gain, plasma lipids by changes in diet composition حسب Bouclaous, Carmel

"…The four groups [group I (HC, placebo), group II (HC, prednisolone), group III (HF, placebo), group IV (HF, prednisolone)] were pair fed and given the mean amount of food eaten by the group with the least amount of energy intake on the previous day. …"
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Revealing the Adoption Factors of Electric Vehicles in Dubai حسب BIN HUMAID, HUDA

"…Electric vehicles (EVs) have gained interest in the last decades, as a significant amount of people in Dubai depend on private vehicles. …"
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Dietary Trichosporon mycotoxinivoron modulates ochratoxin-A induced altered performance, hepatic and renal antioxidant capacity and tissue injury in broiler chickens حسب Sheraz Ahmed Bhatti (9759633)

"…Dietary OTA at all the tested levels induced the hepatic and renal tissue injury as indicated by significant decreased total antioxidant capacity in these organs along with significant decreased (p ≤ 0.05) serum concentrations of total proteins and albumin. …"

A clustering metaheuristic for large orienteering problems حسب Almiqdad Elzein (13141038)

"…The Orienteering Problem is a challenging NP-hard problem, such that obtaining optimal or near optimal solutions usually requires a significant amount of computation for large and even moderately large instances. …"

A snapshot of current medical research: The notion of supply and demand حسب Almutairi, Adel F.

"…Research has never been more in demand and pursued by various health disciplines worldwide as it is at present. Contemplating the amount, type and quality of current medical research over the last decade leads one to consider the driving forces behind such research. …"
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Alterations in blood Lipoprotein & Apolipoprotein B profile induced by moderate acute & chronic alcohol intake in the rat model. (c2002) حسب Berberi, Rania

"…On the other hand, a 3% alcohol consumption (as beer or whisky) maintained for a two months period did not have an effect on fasting plasma TAG concentration while total and LDL cholesterol concentrations showed a significant decrease and HDL cholesterol concentration was moderately increased. …"
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Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation حسب Mai S., El-Shoukrofy

"…Interesting binding interactions with targets of interest were identified by molecular docking studies. …"
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Effect of acute and chronic grapefruit, orange and pineaple juice consumption upon blood lipoprotein synthesis and metabolism in the rat. (c2004) حسب Abou-Khalil, Jamil

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Improved properties and salt rejection of polysulfone membrane by incorporation of hydrophilic cobalt-doped ZnO nanoparticles حسب Muneer M. Ba-Abbad (14151660)

"…Overall, the results of this study showed that embedding a small amount of Co²⁺ ions doped ZnO NPs with PSf has significant potential to be applied in industrial-scale membrane applications.…"

Circular economy application for a Green Stadium construction towards sustainable FIFA world cup Qatar 2022™ حسب Abathar Al-Hamrani (16494884)

"…<p dir="ltr">The construction industry is responsible for a significant amount of raw material consumption and environmental footprints. …"

Phase II National Study: Job Satisfaction and Workplace Environment Among Community Pharmacists in Lebanon: Pre and Post Economic Crisis حسب Salaheddin, Amira Talaat

"…Average weekly working hours decreased from 59.2 hours in Phase 1 to 49.8 hours in Phase II. …"
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Deciphering the In vitro Role of microRNAs miR-21-3p and miR-222-5p In the Regulation of Clostridioides difficile Flagellin-Induced Inflammation حسب Salman, Zeina

"…Functional assays revealed that miR-222-5p overexpression led to a significant increased expression of key pro-inflammatory cytokines, including IL-8 and TNF-α, while knockdown of these miRNAs resulted in their decreased expression. …"
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Prediction of critical total drawdown in sand production from gas wells: Machine learning approach حسب Fahd Saeed Alakbari (10701871)

"…The effects of all independent variables on the CTD are displayed in three-dimensional plots and showed significant interactions.</p> </div><p></p><h2>Other Information</h2> <p> Published in: The Canadian Journal of Chemical Engineering<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1002/cjce.24640" target="_blank">http://dx.doi.org/10.1002/cjce.24640</a></p>…"

Characterizing the dynamics of climate and native desert plants in Qatar حسب Meshal Abdullah (17746950)

"…Vegetation growth depended not only on rainfall amount but also on the number of rainfall events and accumulation. …"

Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy حسب Ajaz A. Bhat (12984701)

"…The complex and dynamic interactions of the secreted cytokines, chemokines, growth factors, and their receptors mediate chronic inflammation and immunosuppressive TME favoring tumor progression, metastasis, and decreased response to therapy. …"