PKD1 is a potential biomarker and therapeutic target in triple-negative breast cancer حسب Caroline Spasojevic (3619418)

"…We found that high <i>PRKD1</i> mRNA levels were significantly and independently associated with a low metastasis-free survival in the whole breast cancer population and in the triple-negative breast cancer (TNBC) subtype specifically. …"

Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications حسب Jingxuan Shan (4711089)

"…<p dir="ltr">Triple-negative breast cancer (TNBC) accounts for ~15–20% of breast cancer (BC) and has a higher rate of early relapse and mortality compared to other subtypes. …"

Transcriptional alterations of protein coding and noncoding RNAs in triple negative breast cancer in response to DNA methyltransferases inhibition حسب Ramesh Elango (7542068)

"…A number of studies have associated alterations in DNMT activity to tumorigenesis; however, the exact role of DNMTs in shaping the genome in triple negative breast cancer (TNBC) is still being unraveled.…"

Liposomal delivery of DK14 chalcone analogue: A promising therapeutic strategy against triple-negative breast cancer حسب Azza Suliman (23124484)

"…<p>Triple negative breast cancer (TNBC) is considered the most aggressive type of breast malignancy. …"

Identification of a Gene Panel Predictive of Triple-Negative Breast Cancer Response to Neoadjuvant Chemotherapy Employing Transcriptomic and Functional Validation حسب Radhakrishnan Vishnubalaji (3563306)

"…<div><p>Triple-negative breast cancer (TNBC) patients exhibiting pathological complete response (pCR) have better clinical outcomes compared to those with residual disease (RD). …"

PD-L1 Blockade by Atezolizumab Downregulates Signaling Pathways Associated with Tumor Growth, Metastasis, and Hypoxia in Human Triple Negative Breast Cancer حسب Reem Saleh (3513056)

"…<div><p>Triple negative breast cancer (TNBC) is the most aggressive type of breast cancer, which shows resistance to common breast cancer therapies, as it lacks the expression of the most common breast cancer targets. …"

The Anti-Cancer Effect of Strained Photoactivatable Polypyridyl Ruthenium(II) Complexes on Non-Small-Cell Lung Cancer and Triple Negative Breast Cancer Cells حسب Fayad, Christelle

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The anti-cancer effect of series of strained photoactivatable Ru(II) polypyridyl complexes on non-small-cell lung cancer and triple negative breast cancer cells حسب Fayad, Christelle

"…This study investigates the photochemistry and the effect of four strained photoactivatable polypyridyl ruthenium(II) complexes on non-small-cell lung cancer (A549) and triple negative breast cancer (MDA-MB-231) cells. All four ruthenium(II) complexes, [Ru(bpy)2dmbpy]Cl2 (C1) where (bpy = 2,2′-bipyridine and dmbpy = 6,6′-dimethyl-2,2′-bipyridine), [Ru(phen)2dmbpy]Cl2 (C2) where (phen = 1,10-phenanthroline), [Ru(dpphen)2dmbpy]Cl2 (C3) (where dpphen = 4,7-diphenyl-1,10-phenanthroline) and [Ru(BPS)2dmbpy]Na2 (C4) where (BPS = bathophenanthroline disulfonate) eject the dmbpy ligand upon activation by blue light. …"
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Metabolic heterogeneity in TNBCs: A potential determinant of therapeutic efficacy of 2-deoxyglucose and metformin combinatory therapy حسب Samson Mathews Samuel (11008848)

"…<p dir="ltr">Breast cancers (BCs) remain the leading cause of cancer-related deaths among women worldwide. …"

Ethnobotanical survey of medicinal plants used in management of breast cancers in Qatar حسب Rasha.S.Abo, El Alaa

"…Breast cancer is a global health concern, including in Qatar, where it impacts women significantly. …"
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miRNA-dependent regulation of STIM1 expression in breast cancer حسب Rashmi P. Kulkarni (18618634)

"…We show that STIM1 expression is regulated post-transcriptionally by the miRNA machinery and identify miR-223 and miR-150 as regulators of STIM1 expression in the luminal non-aggressive MCF7 breast cancer cell line. In contrast, STIM1 expression in the more aggressive basal triple-negative MDA-MB-231 cell line is not significantly modulated by a single miRNA species but is rather upregulated due to inhibition of the miRNA machinery through downregulation of Ago2. …"

Anti-Angiogenic Effects of Phytochemicals on miRNA Regulating Breast Cancer Progression حسب Elizabeth Varghese (11008845)

"…In the current article, we identify different miRNAs that regulate tumor angiogenesis in the context of oncogenic signaling and metabolic reprogramming in ECs and review how selected phytochemicals could modulate miRNA levels to induce an anti-angiogenic action in breast cancer. Studies involving genistein, epigallocatechin gallate (EGCG) and resveratrol demonstrate the regulation of miRNA-21, miRNA-221/222 and miRNA-27, which are prognostic markers in triple negative breast cancers (TNBCs). …"

Anti-cancer Evaluation of Lebanese Cannabis Oil Extract on Lung and Breast Cancer Cells حسب Saliba, Jane

"…In this study, we look at the anti-tumorigenic effects of Lebanese COE on non-small cell lung cancer cell line (NSCLC) A549 and the triple negative breast cancer cell line (MDA-MB-231). GC-MS analysis of COE revealed CBD dominance (59.1%) followed by THC (20.2%). …"
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HER2-positive apocrine carcinoma of the breast: a population-based analysis of treatment and outcome حسب Faruk Skenderi (6616190)

"…<h2>Purpose</h2> <p>Apocrine carcinoma of the breast (APO) expresses HER2 in 30–50% of cases. This study explored the clinicopathological features and outcome of HER2+/APO and matched HER2+/NST cohort.…"

The Effect of Sodium Butyrate and Sodium Propionate on Breast Cancer Cell Migration and Epithelial-to-Mesenchymal Transition (EMT) حسب Kharazi, Dania

"…While their effect has been well-defined in colorectal cancer, their therapeutic potential and the underlying mechanisms involved remain elusive in breast cancer. This study aims to investigate the anti-tumor effects of NaB and NaP in two distinct breast cancer cell lines, the luminal epithelial-like MCF-7 and the triple-negative mesenchymal-like MDA-MB-231. …"
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Ultrasonically Triggered Release of Folic Acid-Conjugated Liposomes for Breast Cancer Therapy Within Microfluidic Devices حسب AlHazaimeh, Taima Khair Alla

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Dual-labeled trastuzumab-based imaging agent for the detection of human epidermal growth factor receptor 2 overexpression in breast cancer حسب Sampath, Lakshmi

"…Methods: Fluorescence microscopy and confocal microscopy were used to determine the molecular specificity of (DTPA)n-trastuzumab-(IRDye800)m in vitro in SKBr3 (HER2-positive) and MDA-MB-231 (HER2-negative) breast cancer cells. SKBr3 cells were incubated with (DTPA)n-trastuzumab-(IRDye800)m or IRDye800CW or pretreated with trastuzumab or human IgG followed by (DTPA)n-trastuzumab-(IRDye800)m and examined under a fluorescence microscope. …"
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Ultrasound Triggered Release of Estrone- Targeted Liposomes حسب Kawak, Pierre

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A photoactivatable Ru (II) complex bearing 2,9-diphenyl-1,10-phenanthroline حسب Mansour, Najwa

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Development of a cancer metastasis-on-chip assay for high throughput drug screening حسب Lutfiye Yildiz Ozer (17732619)

"…<p dir="ltr">Metastasis is the cause of most triple-negative breast cancer deaths, yet anti-metastatic therapeutics remain limited. …"