يعرض 1 - 20 نتائج من 97 نتيجة بحث عن '(( significant binding based ) OR ( significant ((small decrease) OR (substantial decrease)) ))', وقت الاستعلام: 0.12s تنقيح النتائج
  1. 1

    A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity حسب Wesam S. Ahmed (10170053)

    منشور في 2024
    "…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …"
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    Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells حسب Nihal AlMuraikhi (6002234)

    منشور في 2019
    "…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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    Coevolving residues distant from the ligand binding site are involved in GAF domain function حسب Wesam S. Ahmed (10170053)

    منشور في 2025
    "…<p dir="ltr">Ligand binding to GAF domains regulates the activity of associated catalytic domains in various proteins, such as the cGMP-hydrolyzing catalytic domain of phosphodiesterase 5 (PDE5) activated by cGMP binding to GAFa domain. …"
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    Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model حسب Sahar Isa Da’as (18288880)

    منشور في 2022
    "…Furthermore, heart transcriptome profiling showed a significant downregulation of the actin-filament-based process, indicating an impaired actin cytoskeleton organization as the main dysregulating factor associated with the early ventricular cardiac hypertrophy in the zebrafish mypbc3 HCM model.…"
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    Optimizing the number of players and training bout durations in soccer small‐sided games: Effects on mood balance and technical performance حسب Zouhaier Farhani (22330693)

    منشور في 2025
    "…Therefore, coaches should consider longer continuous bouts when planning SSGs‐based training to significantly decrease TMD and enhance technical‐tactical performance in soccer SSGs.…"
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    YOLO-DefXpert: An Advanced Defect Detection on PCB Surfaces Using Improved YOLOv11 Algorithm حسب Prabu Selvam (22330264)

    منشور في 2025
    "…Accurately identifying small defects on PCB surfaces remains a considerable challenge, particularly under complex background conditions, due to the intricate and compact layout of the boards. …"
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    Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping حسب Karsten Suhre (67967)

    منشور في 2024
    "…Most previous work has been conducted using affinity-based proteomics approaches. These technologies face challenges, such as uncertainty regarding target identity, non-specific binding, and handling of variants that affect epitope affinity binding. …"
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    Efficient mechanochemical synthesis of new fluorinated Schiff bases: a solvent-free, alternative to conventional method with mercury adsorption properties حسب Mirza T. Baig (14152407)

    منشور في 2025
    "…The synthesized fluorinated Schiff bases are evaluated for their adsorption capacity and efficiency in mercury removal and compared to assess their performance, demonstrating that ball milling produced compounds with comparable physical attributes to those produced via traditional solvent-based procedures. …"
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    Computational identification of genetic subnetwork modules associated with maize defense response to Fusarium verticillioides حسب Mansuck Kim (19570903)

    منشور في 2015
    "…The other two predicted modules were indirectly involved in the defense response, where the most significant GO terms associated with these modules were GO:0046914 (transition metal ion binding) and GO:0046686 (response to cadmium ion). …"
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    SARS‐CoV‐2 infection triggers more potent antibody‐dependent cellular cytotoxicity (ADCC) responses than mRNA‐, vector‐, and inactivated virus‐based COVID‐19 vaccines حسب Hadeel T. Zedan (12535521)

    منشور في 2024
    "…Although post‐mRNA vaccination BTI elicited high levels of binding and NAbs, ADCC activity was significantly reduced. …"
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    Past, present and future global mangrove primary productivity حسب Mark Chatting (5728340)

    منشور في 2024
    "…However, significant regional changes were identified, including substantial increases in NPP in the Southwest Australian Shelf (60.58 ± 97.9 %), the Warm Temperate Northeast Pacific (43.75 ± 65.7 %), and the Warm Temperate Northwest Pacific (31.55 ± 55.7 %), as well as decreases in <u>Southeast Asian </u>provinces like the Java Transitional (11.45 ± 6.2 %) and Western Coral Triangle (7.61 ± 9.6 %). …"
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    Redox Homeostasis and Inflammation Responses to Training in Adolescent Athletes: a Systematic Review and Meta-analysis حسب Evdokia Varamenti (8154642)

    منشور في 2020
    "…Following more extended training periods, GSH showed moderate increases (ES 1.131; 95% CI 0.350 to 1.913;<i>Z</i>= 2.839,<i>p</i>= 0.005) while TBARS displayed a small decrease (ES 0.568; 95% CI − 0.062 to 1.197;<i>Z</i>= 1.768,<i>p</i>= 0.077). …"
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