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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Microalgal-based desalination brine remediation: Achievements, challenges, and future research trends
منشور في 2024"…The review highlights achievements in microalgae-based brine remediation, including nutrient sequestration and the valorization of microalgal biomass after treatment. …"
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Particle size impact on pyrolysis of multi-biomass: a solid-state reaction modeling study
منشور في 2023"…<p dir="ltr">yrolysis has gained significant attention due to its generation of value-added products from waste feeds in an environmentally friendly manner. …"
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Upgrading co-pyrolysis products from ternary biomass: An investigative study of commercial and locally-made catalysts
منشور في 2024"…<p dir="ltr">Catalysts play a pivotal role in influencing product yields and compositions in pyrolysis processes, offering significant advantages for biomass conversion. This study investigates the impact of natural and commercial catalysts on the co-pyrolysis of ternary biomass at two different temperatures (550 °C and 750 °C). …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Biomass gasification combined with a novel heat integration design for sustainable energy supply programs: Comprehensive thermodynamic, environmental, and economic evaluations
منشور في 2025"…An environmentally friendly substitute for clean energy conversion is municipal solid waste (MSW), a resource that is widely accessible. However, previous biomass-based systems frequently have issues with efficiency, economic viability, and emissions. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Sustainable energy-water-food nexus integration and carbon management in eco-industrial parks
منشور في 2023"…The total cost of the optimum solution after biomass utilisation is almost 3% more expensive compared to the base scenario. …"
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A systematic review on hydrogen production via hydrochar-based gasification
منشور في 2025"…This systematic review explores hydrogen production through hydrochar-based gasification technologies, focusing on the unique properties of hydrochar derived from biomass. …"
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Harnessing microalgae for a synergistic approach to CO₂ capture, wastewater treatment, and biodiesel production: A review
منشور في 2025"…Under optimized mixotrophic conditions, C. vulgaris achieves biomass concentrations of 4.0 g/L with 20–40 % lipid content, supporting viable biodiesel yields. …"