-
1
-
2
A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
-
3
Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
-
4
-
5
Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
-
6
Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
-
7
-
8
-
9
Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
-
10
Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through...
منشور في 2021"…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
article -
11
The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
-
12
Investigating Educators’ Perceptions of the Impact of STEM Project-Based Learning on 21st Century Skills
منشور في 2024"…This study investigates educators' perspectives on STEM Project-Based Learning (PBL) implementation and its effectiveness in fostering 21st century skills in private American schools in Ajman, UAE. …"
احصل على النص الكامل
-
13
Assessing Factors Influencing Customers’ Adoption of AI-Based Voice Assistants
منشور في 2024"…The study reveals that the “value of openness to change” poses a significant effect toward “reasons for” adoption, among which “performance expectancy” and “hedonic motivation” play the most significant role in establishing a favorable attitude toward voice assistants’ adoption. …"
-
14
A Blockchain-Based Scalability Solution with Microgrids Peer-to-Peer Trade
منشور في 2024"…This study proposes a blockchain-based scalability solution with a focus on P2P energy trading. …"
-
15
AI-based remaining useful life prediction and modelling of seawater desalination membranes
منشور في 2024احصل على النص الكامل
doctoralThesis -
16
What is the impact of implementing problem-based learning (PBL) in school curricula on the development of critical thinking abilities in elementary students?
منشور في 2025"…This study examines the effect of implementing Problem-Based Learning (PBL) in elementary school curricula on the development of critical thinking skills among students. …"
احصل على النص الكامل
-
17
A novel spherical fuzzy-based decision model for assessing data management maturity in governmental institutions
منشور في 2025"…The criteria were subjectively weighted by an expert panel (SME) to reflect the significance of each criterion in a government setting. …"
-
18
A Diffusion-Based Probabilistic Ultra-Short-Term Solar Power Prediction Using the Sky Image Sequences
منشور في 2025"…<p dir="ltr">The inherently unpredictable nature of solar power generation, primarily due to rapidly changing cloud cover, poses a significant challenge to the operation of solar-integrated energy systems. …"
-
19
Hyper-Hypo study: A Retrospective Observational Study of Neonatal Hypoglycemia Related to Maternal Hypertension
منشور في 2023"…However, a sub-group comparison of neonates (with initial blood glucose <2.6 mmol/L) showed methyldopa to be marginally associated with a 2 mmol/L decrease from the mean initial blood glucose, mean 1.6 ± 0.5 mmol/L, and methyldopa (1.4 ± 0.5 mmol/L; p= .045). …"
-
20
Rescue cerclage
منشور في 2006"…Advanced dilation of 3 cm and/or prolapsed membranes (n = 18) did not decrease the likelihood of reaching 28 weeks. Mean gestational age at delivery for this subset of patients was 30.7 ± 7.2 weeks. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
article