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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Causes of construction reworks and their mitigation strategies
منشور في 2018"…Further going forward hypothesis results and case studies comparison discussed which concluded that literature review, SPSS results and case studies are totally aligned about route causes and further mitigation techniques. …"
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Business Streamlining: Towards Sustained Business Process Improvement with implementation of Total Quality Management Tools
منشور في 2023"…This dissertation presents a case study of a company afflicted by inefficient business processes. …"
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Causes of Delay in Construction Projects in Oil and Gas Construction Industry
منشور في 2017"…With regard to design, the contractor’s need to decrease construction costs through a cheaper design was found to be a factor in design changes. …"
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Brucellar cervical epidural abscess - A rare cause of neck pain
منشور في 2021"…The combination of the therapeutic strategies we used lead to a significant clinical improvement in this rare case.</p><h2>Other Information</h2><p dir="ltr">Published in: IDCases<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.idcr.2021.e01101" target="_blank">https://dx.doi.org/10.1016/j.idcr.2021.e01101</a></p>…"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Optimization of p-chart for Processes with Multiple Assignable Causes and Random Shift
منشور في 2020احصل على النص الكامل
doctoralThesis -
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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The European Union's role in tackling the root causes of migration in Tunisia and Libya. (c2015)
منشور في 2015"…This thesis seeks to describe and analyze this debate and use Libya and Tunisia as case studies illustrating the challenges of addressing what many are calling the largest wave of migration in Europe since World War Two.…"
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masterThesis -
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