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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…The expression of certain genes involved in proliferation and apoptosis was measured using reverse transcriptase‑polymerase chain reaction (RT‑PCR) and western blotting. To assess the effect of kefir on cancer metastasis, wound‑healing and time‑lapse movies, in addition to collagen‑based invasion assay, were used. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Oral contraceptive pills and possible adverse effects
منشور في 2014"…Since their introduction to the market, there have been significant changes in the drug content and formulations of these products, in part to decrease the risk of adverse effects. …"
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Multi-IsnadSet MIS for Sahih Muslim Hadith with chain of narrators, based on multiple ISNAD
منشور في 2024"…The graph representation of the authentic and manually curated dataset will open ways for the development of computational models that could identify the significance of a chain and a narrator. The dataset allows the researchers to provide Hadith narrators and Hadith ISNAD that could be used in a wide variety of future research studies related to Hadith authentication and rules extraction. …"
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The Impact of a Computerized Potassium Alert on Adverse Drug Events and Pharmacists' Interventions
منشور في 2010"…Conclusions: Implementation of a computerized pharmacy alert resulted in a statistically significant decrease in adverse drug events related to hyperkalemia in our institution. …"
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QFD-based optimization model for mitigating sustainable supply chain management adoption challenges for Bangladeshi RMG industries
منشور في 2024"…The optimal solution incorporates green strategies, technology integration, and aspects of Industry 5.0, demonstrating a holistic approach to sustainable supply chain management. The findings are crucial for Bangladeshi RMG industries aiming for global market competitiveness and contribute significantly to the academic field by introducing a robust, data-driven decisions for sustainable supply chain optimization. …"
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Security Supply Chain Using UAVs: Validation and Development of a UAV-Based Model for Qatar’s Mega Sporting Events
منشور في 2023"…The key findings of the study are: (1) a valid and reliable UAV-based cybersecurity framework for FIFA mega sporting events was developed; (2) five critical factors were identified, including traceability, security and privacy, trust, acceptability, and preparedness; (3) all factors were significantly and positively correlated, highlighting the complexity of managing security systems in mega sporting events.…"
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Integrated operational and financial approaches in supply chain risk management
منشور في 2012"…We develop a (base) stochastic optimization model that incorporates operational and financial features of the aforementioned supply chain. …"
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Green Supply Chains: A Comparative Efficiency Analysis in the Gulf and Beyond
منشور في 2023"…Strong contenders in green supply chains include the UAE, Oman, México, Panamá, and Ecuador.…"
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Interconnectedness between Supply Chain Resilience, Industry 4.0, and Investment
منشور في 2023"…These circumstances demand significant paradigm shifts, placing supply chain resilience (SCR) in the foreground of boardrooms and agendas of executive meetings. …"