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يعرض 1 - 20 نتائج من 975 نتيجة بحث عن '(( significant challenge model ) OR ( significant ((we decrease) OR (a decrease)) ))', وقت الاستعلام: 0.13s تنقيح النتائج
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    A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity حسب Wesam S. Ahmed (10170053)

    منشور في 2024
    "…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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    Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex حسب Wesam S. Ahmed (10170053)

    منشور في 2022
    "…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
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    Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells حسب Nihal AlMuraikhi (6002234)

    منشور في 2019
    "…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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    The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu... حسب Wesal Habbab (17346961)

    منشور في 2019
    "…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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    Editorial: At the Crossroads: Lessons and Challenges in Computational Social Science حسب Javier Borge-Holthoefer (211484)

    منشور في 2016
    "…At the turn of the century, however, it was clear that huge challenges—and new opportunities— lied ahead: the digital communication technologies, and their associated data deluge, began to nurture those models with empirical significance. …"
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    QFD-based optimization model for mitigating sustainable supply chain management adoption challenges for Bangladeshi RMG industries حسب Md Al Amin (17808299)

    منشور في 2024
    "…The implications extend beyond the RMG sector, offering a replicable model for other industries and regions facing similar sustainability challenges.…"
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    Implementing a collaborative care model for child and adolescent mental health in Qatar: Addressing workforce and access challenges حسب Mohamed Adil Shah Khoodoruth (14589828)

    منشور في 2024
    "…This commentary explores the model’s feasibility, addressing challenges like workforce shortages and psychotropic prescribing processes. …"
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    Survey of Multimodal Federated Learning: Exploring Data Integration, Challenges, and Future Directions حسب Mumin Adam (22466626)

    منشور في 2025
    "…Traditional machine learning (ML) models rely on centralized architectures, which, while powerful, often present significant privacy risks due to the centralization of sensitive data. …"
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    Impact of AI and Dynamic Ensemble Techniques in Enhancing Healthcare Services: Opportunities and Ethical Challenges حسب Haseeb Javed (18576340)

    منشور في 2024
    "…Dynamic ensemble techniques, which leverage multiple predictive models to improve outcome accuracy, offer significant promise in addressing the complexities of patient data and disease manifestations. …"
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    Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment حسب Amal Sabouni (17046236)

    منشور في 2023
    "…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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    Deep random vector functional link transformer network with multiple output layers for significant wave height forecasting حسب Aryan Bhambu (18767731)

    منشور في 2025
    "…<p>Accurate control of wave energy devices relies heavily on precise forecasts of wave heights, yet the dynamic and fluctuating nature of historical wave data presents significant challenges to achieving this precision. …"