-
1
A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
-
2
-
3
-
4
Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
-
5
-
6
Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
-
7
The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
-
8
-
9
Identifying and Assessing the Significance of Digital Twin Enablers in the Construction Industry
منشور في 2025احصل على النص الكامل
doctoralThesis -
10
-
11
Editorial: At the Crossroads: Lessons and Challenges in Computational Social Science
منشور في 2016"…At the turn of the century, however, it was clear that huge challenges—and new opportunities— lied ahead: the digital communication technologies, and their associated data deluge, began to nurture those models with empirical significance. …"
-
12
QFD-based optimization model for mitigating sustainable supply chain management adoption challenges for Bangladeshi RMG industries
منشور في 2024"…The implications extend beyond the RMG sector, offering a replicable model for other industries and regions facing similar sustainability challenges.…"
-
13
Implementing a collaborative care model for child and adolescent mental health in Qatar: Addressing workforce and access challenges
منشور في 2024"…This commentary explores the model’s feasibility, addressing challenges like workforce shortages and psychotropic prescribing processes. …"
-
14
Survey of Multimodal Federated Learning: Exploring Data Integration, Challenges, and Future Directions
منشور في 2025"…Traditional machine learning (ML) models rely on centralized architectures, which, while powerful, often present significant privacy risks due to the centralization of sensitive data. …"
-
15
-
16
-
17
Impact of AI and Dynamic Ensemble Techniques in Enhancing Healthcare Services: Opportunities and Ethical Challenges
منشور في 2024"…Dynamic ensemble techniques, which leverage multiple predictive models to improve outcome accuracy, offer significant promise in addressing the complexities of patient data and disease manifestations. …"
-
18
-
19
Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
-
20
Deep random vector functional link transformer network with multiple output layers for significant wave height forecasting
منشور في 2025"…<p>Accurate control of wave energy devices relies heavily on precise forecasts of wave heights, yet the dynamic and fluctuating nature of historical wave data presents significant challenges to achieving this precision. …"