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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Identifying and Assessing the Significance of Digital Twin Enablers in the Construction Industry
منشور في 2025احصل على النص الكامل
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Editorial: At the Crossroads: Lessons and Challenges in Computational Social Science
منشور في 2016"…At the turn of the century, however, it was clear that huge challenges—and new opportunities— lied ahead: the digital communication technologies, and their associated data deluge, began to nurture those models with empirical significance. …"
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QFD-based optimization model for mitigating sustainable supply chain management adoption challenges for Bangladeshi RMG industries
منشور في 2024"…The implications extend beyond the RMG sector, offering a replicable model for other industries and regions facing similar sustainability challenges.…"
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Implementing a collaborative care model for child and adolescent mental health in Qatar: Addressing workforce and access challenges
منشور في 2024"…This commentary explores the model’s feasibility, addressing challenges like workforce shortages and psychotropic prescribing processes. …"
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Survey of Multimodal Federated Learning: Exploring Data Integration, Challenges, and Future Directions
منشور في 2025"…Traditional machine learning (ML) models rely on centralized architectures, which, while powerful, often present significant privacy risks due to the centralization of sensitive data. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Impact of AI and Dynamic Ensemble Techniques in Enhancing Healthcare Services: Opportunities and Ethical Challenges
منشور في 2024"…Dynamic ensemble techniques, which leverage multiple predictive models to improve outcome accuracy, offer significant promise in addressing the complexities of patient data and disease manifestations. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Deep random vector functional link transformer network with multiple output layers for significant wave height forecasting
منشور في 2025"…<p>Accurate control of wave energy devices relies heavily on precise forecasts of wave heights, yet the dynamic and fluctuating nature of historical wave data presents significant challenges to achieving this precision. …"
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Power System Stability With High Penetration of Renewable Energy Sources: Challenges, Assessment, and Mitigation Strategies
منشور في 2025"…<p dir="ltr">The incorporation of renewable energy sources (RESs) into power systems has significantly increased in recent years due to growing environmental, economic, and energy security concerns, posing new challenges for power system stability. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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احصل على النص الكامل
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