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Increasing methylation of sperm rDNA and other repetitive elements in the aging male mammalian germline
منشور في 2020"…Here, we used bisulfite pyrosequencing and show that methylation of the rDNA transcription unit including upstream control element (UCE), core promoter, 18S rDNA, and 28S rDNA in human sperm also significantly increases with donor's age. This positive correlation between sperm rDNA methylation and biological age is evolutionarily conserved among mammals with widely different life spans such as humans, marmoset, bovine, and mouse. …"
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Changes in the burden and underlying causes of heart failure in the Eastern Mediterranean Region, 1990–2019: an analysis of the Global Burden of Disease Study 2019
منشور في 2023"…InterpretationThe burden of HF in the EMR was higher than the global, with increasing age-standardised prevalence and YLDs in countries of the region. …"
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article -
4
Significance of Avicennia Marina in the Arabian Gulf Environment: A Review
منشور في 2025"…<i>Avicennia marina</i> is the only mangrove species found in the Arabian Gulf (hereafter the ‘Gulf’) coastal region, marking the northernmost boundary of mangroves in the Indo-Pacific region. …"
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Board changes and CEO turnover
منشور في 2014"…For firms that decrease independence, the CEO turnover performance sensitivity significantly decreases following SOX. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…<p dir="ltr">NanoLuc (NLuc) <u>luciferase</u> has found extensive application in designing a range of <u>biologica</u><u>l</u><u> assays,</u> including <u>gene expression analysis</u>, protein-protein interaction, and protein conformational changes due to its enhanced brightness and small size. …"
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Challenges and practices identification in complex outsourcing relationships: A systematic literature review
منشور في 2022"…However, by virtue of its complexity, the complex outsourcing typically necessitates the interactions among various stakeholders from diverse regions and cultures, making it significantly more challenging to manage than traditional outsourcing. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Global gene expression profiling of LY411575-treated cells revealed changes in multiple signaling pathways, including focal adhesion, insulin, TGFβ, IL6, and Notch signaling, and decreased the expression of genes associated with functional categories of tissue development. …"
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Vocal Changes in Patients With Polycystic Ovary Syndrome
منشور في 2011"…There was no statistically significant difference in the acoustic parameters except for an increase in the relative average perturbation (P value = 0.035) and a decrease in maximum phonation time (P value = 0.001) in patients with PCOS. …"
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Gestational Diabetes in the Gulf Region: Streamlining care to optimise outcome
منشور في 2015"…<p dir="ltr">The burden of gestational diabetes mellitus (GDM) has notably been on the increase in many countries. This observed trend feeds into the growing problem of obesity and type 2 diabetes, especially in regions with higher background prevalence of diabetes such as the Gulf Cooperation Countries (GCC). …"
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Estimating Economic and Environmental Benefits of Urban Trees in Desert Regions
منشور في 2020"…<p>Trees in urban areas have a significant impact on air quality and other environmental issues. …"
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13
Essays on the effect of excess compensation and governance changes on firm value
منشور في 2012"…This dissertation consists of three essays on the effect of excess compensation and corporate governance changes on the firm’s performance. The first paper utilizes a cost minimization stochastic frontier approach to investigate the efficiency of director total compensation. …"
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masterThesis -
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Metabolomics of Dynamic Changes in Insulin Resistance Before and After Exercise in PCOS
منشور في 2019"…While compering within the groups, no significant changes in the amino acid levels before and after exercise were observed. …"
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Exploring environmental, social, and governance and bank performance in the Gulf Cooperation Council region
منشور في 2023"…<p dir="ltr">Corporate strategies today are shaped by the increased importance given by companies, investors, and regulators to environmental, social, and governance (ESG) activities. …"
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Understanding dispute resolution in the Middle East region from perspectives of different stakeholders
منشور في 2016"…However, this growth is accompanied by an inevitable increase in claims and disputes, which consequently leads to significant delays and additional costs to the project. …"
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article -
18
Land use and limitations in the sinkhole and polje karst of the Ksiromero Region, Western Greece
منشور في 2013"…Shallow groundwater occurs in some of these reservoirs, as well as seasonally captured storm water, but much is pumped in from the adjacent region or from nearby wells. This system is adequate for the area's modest water needs, but not for potential increased demand. …"
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19
Modulation of SLFN11 induces changes in DNA Damage response in breast cancer
منشور في 2023"…The use of a CRISPR-dCas9 UNISAM and KRAB system could increase or decrease SLFN11 expression significantly (up to fivefold), stably and specifically in BT-549 and T47D cancer cell lines. …"
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Conceptual Skills in Leading Change: A Competence Approach to Public Sector Leadership
منشور في 2019"…Leaders’ capacity to think about abstract and complex ideas has long been acknowledged as essential to leadership tasks such as planning and analysis; however, because conceptualisation is often ambiguous and difficult to understand, many frameworks of leadership and change lack clarity on the actual significance of leaders’ conceptual skills when leading change. …"
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