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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Detection of statistically significant network changes in complex biological networks
منشور في 2017"…</p><h3>Methods</h3><p dir="ltr">In this paper, we propose an improvement over the state-of-the-art based on the Generalized Hamming Distance adopted for evaluating the topological difference between two networks and estimating its statistical significance. The proposed procedure exploits a more effective model selection criteria to generate <i>p</i>-values for statistical significance and is more efficient in terms of computational time and prediction accuracy than literature methods. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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An examination of how climate change could affect the future spread of Fusarium spp. around the world, using correlative models to model the changes
منشور في 2023"…Climate change is predicted to have a significant impact on the geographic distribution of various flora, fauna, and insect species by expanding, contracting, or shifting their suitable climate environment. …"
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An examination of how climate change could affect the future spread of <i>Fusarium</i> spp. around the world, using correlative models to model the changes
منشور في 2023"…<p dir="ltr"><u>Climate change</u> is predicted to have a significant impact on the geographic distribution of various flora, fauna, and insect species by expanding, contracting, or shifting their suitable climate environment. …"
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Hydrodynamic Modelling of Sharjah lagoons (UAE) under Climate Changes
منشور في 2022احصل على النص الكامل
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Numerical modelling of hyperbolic phase change problems: Application to continuous casting
منشور في 2023"…In this paper, we develop a mathematical formulation to predict the finite speed of heat propagation in multidimensional phase change problems. The model generalizes the enthalpy formulation by adding a hyperbolic term. …"
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Numerical modelling of hyperbolic phase change problems: Application to continuous casting
منشور في 2023"…In this paper, we develop a mathematical formulation to predict the finite speed of heat propagation in multidimensional phase change problems. The model generalizes the enthalpy formulation by adding a hyperbolic term. …"
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Analyzing hydrodynamic changes in the Dubai Creek: a pre- and post-extension study
منشور في 2023احصل على النص الكامل
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Identifying and Assessing the Significance of Digital Twin Enablers in the Construction Industry
منشور في 2025احصل على النص الكامل
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Using Artificial Intelligence to Understand What Causes Sentiment Changes on Social Media
منشور في 2021"…The framework utilizes cascaded LDA Models with multiple settings of hyperparameters to capture candidate reasons that cause sentiment changes. …"
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Modeling the influence of daily temperature and precipitation extreme indices on vegetation dynamics in Katsina State using statistical downscaling model (SDM)
منشور في 2023"…<p>Climate change significantly impacts local, regional, and global vegetation changes. …"
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Exploring urban growth–climate change–flood risk nexus in fast growing cities
منشور في 2022"…In addition, Doha witnessed various climatic changes with a notable increase in air temperature (+ 8.7%), a decrease in surface wind speed (− 19.5%), and a decrease in potential evapotranspiration losses (− 33.5%). …"