-
1
A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
-
2
-
3
-
4
Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
-
5
-
6
Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
-
7
The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
-
8
-
9
Managing change process: A case study of a private school in Sharjah
منشور في 2016"…The significance of change process management increases as the modern world trends of education and learning require a change. …"
احصل على النص الكامل
-
10
Identifying and Assessing the Significance of Digital Twin Enablers in the Construction Industry
منشور في 2025احصل على النص الكامل
doctoralThesis -
11
-
12
Conceptual Skills in Leading Change: A Competence Approach to Public Sector Leadership
منشور في 2019"…The thesis concludes on the significance of individuals’ conceptual skills in leading public sector change by presenting a framework of conceptual skills relevant to four areas of leadership: self-regulation, sensemaking, integrative leadership and innovative leadership. …"
احصل على النص الكامل
-
13
-
14
Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
-
15
Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
-
16
An evaluation of recruitment and selection processes in three organizations in the UAE
منشور في 2011"…Finally, some recommendations are offered to assist UAE organizations with focusing more carefully on good practice, changing and developing solutions to minimize the problems that typically arise from inadequate recruitment and selection processes.…"
احصل على النص الكامل
-
17
Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
article -
18
Experimental Validation of Numerical Model for Thermomechanical Performance of Material Extrusion Additive Manufacturing Process: Effect of Process Parameters
منشور في 2022"…The numerical models and simulation tools can predict the thermomechanical performance of the MEAM process under given input parameters (material, design, and process variables) and reduce the research and development costs significantly. …"
-
19
Numerical modelling of hyperbolic phase change problems: Application to continuous casting
منشور في 2023"…Heat diffusion processes are generally modeled based on Fourier’s law to estimate how the temperature propagates inside a body. …"
احصل على النص الكامل
article -
20
Numerical modelling of hyperbolic phase change problems: Application to continuous casting
منشور في 2023"…Heat diffusion processes are generally modeled based on Fourier’s law to estimate how the temperature propagates inside a body. …"
احصل على النص الكامل
article