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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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An Infrastructure-Assisted Crowdsensing Approach for On-Demand Traffic Condition Estimation
منشور في 2019"…The proposed solution was validated through a combination of prototyping and simulated traffic traces, and the results show a significant reduction in terms of resources' consumption and network overhead, while reaching high accuracy for the traffic condition estimation.…"
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Characterization of MXene as a Cancer Photothermal Agent Under Physiological Conditions
منشور في 2021"…Interestingly, dynamic culture alone did not result in a significant increase in uptake suggesting the need for surface modifications for enhanced cellular uptake under shear stress. …"
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A novel on-demand vehicular sensing framework for traffic condition monitoring
منشور في 2018"…With the increased need for mobility and the overcrowding of cities, the area of Intelligent Transportation aims at improving the efficiency, safety, and productivity of transportation systems by relying on communication and sensing technologies. …"
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Central air conditioning, air pollution and housing location: evidence from Lebanon
منشور في 2022"…The estimated increase in the probability of having central air conditioning for a one microgram per cubic meter increase in Particulate Matter 2.5 concentration is 6.4%. …"
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Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines
منشور في 2018"…Complex 1 demonstrated only marginal activity in the dark; its cytotoxicity increased significantly upon photoactivation with a high phototoxicity index (PI = [IC50 dark]/[IC50 light]) ranging from 39.2‐fold in A549 to over 100‐fold in MDA‐MB‐231. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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A novel integrated wastewater recovery, clean water production and air-conditioning system
منشور في 2021"…<p dir="ltr">Ensuring water and energy security for the growing global population is a challenge that aggravates several folds if in water-scarce regions, accustomed to prevailing hot climates and coupled with the increasing per capita demand of these resources. Furthermore, in hot and arid regions, the largest portion of energy is consumed by air-conditioning in buildings. …"
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Colloid retention and mobilization mechanisms under different physicochemical conditions in porous media: A micromodel study
منشور في 2021"…However, for hydrophobic colloids, changes in solution chemistry significantly increase colloid retention where the colloid interaction become attractive with the increase in ionic strength and decrease in pH values. …"
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Effect of Climate Change on the Energy Performance and Thermal Conditions of a Single-family Detached House in Canada
منشور في 2019"…The overheating hours would be increased by 27-43% for the NECB case, 44-50% for the PH case, respectively, under predicted 2090 weather conditions without natural ventilation. …"
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