-
1
A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
-
2
-
3
-
4
Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
-
5
-
6
The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
-
7
Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
-
8
-
9
-
10
The effectiveness of physical models in teaching anatomy
منشور في 2016"…The aim of this meta-analysis is to quantitatively assess the effectiveness of such models based on comparative studies. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
article -
11
Detection of statistically significant network changes in complex biological networks
منشور في 2017"…</p><h3>Methods</h3><p dir="ltr">In this paper, we propose an improvement over the state-of-the-art based on the Generalized Hamming Distance adopted for evaluating the topological difference between two networks and estimating its statistical significance. The proposed procedure exploits a more effective model selection criteria to generate <i>p</i>-values for statistical significance and is more efficient in terms of computational time and prediction accuracy than literature methods. …"
-
12
-
13
Stability and bifurcation analysis of a discrete-time predator-prey model with strong Allee effect
منشور في 2020"…In this paper, we investigate the impact of Allee effect on the stability of a discrete-time predator-prey model with a non-monotonic functional response. …"
احصل على النص الكامل
article -
14
Experimental investigation and multi-scale Mori–Tanaka modeling of viscoelastic asphalt mastic with imperfect interfaces
منشور في 2025"…This enhanced performance is attributed to the high surface area of hydrated lime and its chemical interactions with the asphalt binder, which promote the formation of a network structure within the mastic. While the proposed model effectively captures the physical interactions in asphalt mastics, it requires further refinement to account for the additional influence of chemical reactions between fillers, such as hydrated lime, and the asphalt binder.…"
-
15
Contagion effects in a chartist–fundamentalist model with time delays
منشور في 2007"…In this paper two models of speculative markets are developed to study the effects of feedback mechanisms in financial markets. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
article -
16
Staff Development: A Study Into The Significance of Staff Professional Development Programs for Educators and Students Achievement
منشور في 2011"…The concept of staff professional development and its effectiveness has been a key area of discussion for long. …"
احصل على النص الكامل
-
17
Potential Therapeutic Effects of Lebanese Cannabis oil in Female Mouse Models of Neuropsychiatric Disorders
منشور في 2022"…Accordingly, the current research study examined the therapeutic effects of Cannabis oil extracted from the Lebanese Cannabis sativa plant on resilience to stress and its ability to rescue depression and anxiety-like behaviors in female animal models. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
masterThesis -
18
Effects of BIM in Enhancing Prefabricated Construction
منشور في 2021احصل على النص الكامل
doctoralThesis -
19
Non-Newtonian Effects in a Fluid-Structure Interaction Model for Atherosclerosis
منشور في 2009"…The simulations show that the Newtonian model significantly overestimates the recirculations in comparison with the non-Newtonian model. …"
احصل على النص الكامل
احصل على النص الكامل
article -
20
Modeling Human Resource Training Using Social Network Theory and Analytics
منشور في 2022"…Results from social network analysis and partial least squares path modelling show that the social network variables of betweenness, efficiency and tie strength positively impact training, while density and degree have no significant impact. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
masterThesis