Gene Expression and miRNAs Profiling: Function and Regulation in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer حسب Rasha M. Sareyeldin (18131371)

"…Despite the anti-HER2 and cytotoxic chemotherapy, HER2 subtype is an aggressive disease with significant mortality. Recent advances in molecular biology techniques, including gene expression profiling, proteomics, and microRNA analysis, have been extensively used to explore the underlying mechanisms behind human breast carcinogenesis and metastasis including HER2-positive breast cancer, paving the way for developing new targeted therapies. …"

Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a Potential Target for Obesity حسب Mohamed Abu-Farha (18535590)

"…In functional assays, our data indicated that ectopic expression of HDAC4 significantly impaired TNF-α-dependent activation of NF-κB, establishing thus a link between HDAC4 and regulation of the immune system. …"

Downregulation of Lymphoid enhancer‐binding factor 1 (<i>LEF‐1)</i> expression (by immunohistochemistry and/ flow cytometry) in chronic Lymphocytic Leukemia with atypical immunophe... حسب Dina S. Soliman (14779333)

"…The ratio for <i>LEF-1</i> expression in malignant B-cells/NK (by flow cytometry) in CLL/SLL with classic immunophenotype was higher than atypical CLL and is significantly higher in other small B-cell lymphomas (<i>P </i>< .01). …"

iPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes حسب Noura Aldous (15429873)

"…Several important transcription factors (TFs) required for pancreatic islet development and function were significantly downregulated in FOXA2–/–PPs such as PDX1, NKX6.1, SOX9, PAX4, GATA6, NEUROG3, NEUROD1, and PTF1A, which were also validated by RT-qPCR. …"

iPSC-Derived Pancreatic Progenitors Lacking FOXA2 Reveal Alterations in miRNA Expression Targeting Key Pancreatic Genes حسب Noura Aldous (15429873)

"…To identify differentially expressed miRNAs (DEmiRs), and genes (DEGs), two differentFOXA2^–/^–iPSC lines were differentiated into PPs.FOXA2^–/^–PPs showed a significant reduction in the expression of the main PP transcription factors (TFs) in comparison to WT-PPs. …"

The combinatory effects of diet and exercise on BDNF gene expression حسب Bassil, Maya

"…Brain Derived Neurotrophic Factor (BDNF) plays a critical role in the synaptic activity and plasticity of mature neurons and regulates the formation and maintenance of memory. …"
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Analysis of facial emotion expression in eating occasions using deep learning حسب Elif Yildirim (17725965)

"…We measured the neural, behavioral, and physical manifestations of emotions with a mobile app and recognize emotional experiences from facial expressions. In this research, we used three different situations to test whether there could be any factor other than the food that could affect a person’s mood. …"

Differing endometrial expression of calcium modulating transient receptor potential channels حسب Maryam Ghavideldarestani (11862563)

"…</p><p dir="ltr">Endometrial samples at day 21 of the menstrual cycle (MC) from 15 patients (Table 1) prior to ART were taken; five women with normal female investigation, but with male factor infertility (MFI), acted as controls; five women had unexplained infertility (UI) and five had PCOS with no MFI. …"

The unified effect of data encoding, ansatz expressibility and entanglement on the trainability of HQNNs حسب Muhammad Kashif (3923483)

"…Our framework aims to empirically analyze the joint impact of these factors on the training landscape of HQNNs. Our results show that the occurrence of the BP problem in HQNNs is contingent upon the expressibility of the underlying ansatz and the type of the adopted data encoding technique. …"

Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion حسب Khoury, Nathalie

"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of medulloblastoma cells حسب Castellino, R.C.

"…Daoy and D556 human medulloblastoma cells pre-treated for 1 h with 0.2 μM sunitinib demonstrated induction of PTEN expression and significant inhibition of PDGFR signaling activity and transactivation of EGFR, in a RAS-independent manner, in response to PDGF-BB stimulation. …"
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Gene expression data analysis identifies multiple deregulated pathways in patients with asthma حسب Reem H. Alrashoudi (18629731)

"…The data highlight the multifactorial nature of asthma, but revealed no significant overlap with the gene expression profiles from different datasets interrogated in current studies. …"

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... حسب Vijay Ganji (8710491)

The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas حسب Abou-Ghazal, Mohamed

"…We sought to determine the incidence of phosphorylated STAT3 (p-STAT3) expression in malignant gliomas of different pathologic types, whether p-STAT3 expression is a negative prognostic factor, and whether p-STAT3 expression influences the inflammatory response within gliomas. …"
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A positive change in energy balance modulates TrkB expression in the hypothalamus and nodose ganglia of rats حسب Zeeni, Nadine

"…Brain-derived neurotrophic factor (BDNF) and its TrkB receptor play critical roles in the synaptic activity and plasticity of mature neurons and enhance adult neurogenesis. …"
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A jojoba (Simmondsia chinensis) seed cake extracts express hepatoprotective activity against paracetamol-induced toxicity in rats حسب Firas Feki (17545638)

"…The PC intoxication altered the serum biomarkers, the oxidative status, and the Tumor necrosis factor alpha (TNF-α), Bax and Bcl-2 protein expressions of tested animals. …"

Morphological changes in amblyopic eyes in choriocapillaris and Sattler’s layer in comparison to healthy eyes, and in retinal nerve fiber layer in comparison to fellow eyes through... حسب Masri, Oussama Samer

"…Results The method of measuring reflectivity is good to excellent reliability for all regions of interest except the fourth. The mean reflectivity of the choriocapillaris and Sattler’s layer in amblyopic eyes were significantly lower than in healthy eyes (p = 0.003 and p = 0.008 respectively). …"
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Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and SNAI1 Expression Levels and Predicts Breast Cancer Patients Response حسب Noura Al-Zeheimi (5177066)

"…From a panel of tested proteins and genes, we found that the levels of plasma NRP-1, placenta growth factor (PlGF) and immune cell expression of the transcription factor <i>SNAI1</i> before and after NAC were significantly different. …"

When digital spaces matter: The influence of uniqueness and place attachment on self-identity expression with brands using generative AI on the metaverse حسب Farah, Maya F.

"…The goal was to understand how the need for uniqueness influences self-identity expression and to examine how these factors are affected by attachment to virtual places. …"
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Local Over-Expression of VEGF-DDNDC in the Uterine Arteries of Pregnant Sheep Results in Long-Term Changes in Uterine Artery Contractility and Angiogenesis حسب Abi Nader, Khalil

"…Reduced uterine artery blood flow (UABF) is a common cause of fetal growth restriction; abnormalities in angiogenic factors are implicated. Previously we showed that adenovirus (Ad)-mediated VEGF-A165 expression in the pregnant sheep uterine artery (UtA) increased nitric oxide synthase (NOS) expression, altered vascular reactivity and increased UABF. …"
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