A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity حسب Wesam S. Ahmed (10170053)

"…<p dir="ltr">NanoLuc (NLuc) <u>luciferase</u> has found extensive application in designing a range of <u>biologica</u><u>l</u><u> assays,</u> including <u>gene expression analysis</u>, protein-protein interaction, and protein conformational changes due to its enhanced brightness and small size. …"

Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells حسب Nihal AlMuraikhi (6002234)

"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"

Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion حسب Khoury, Nathalie

"…The expression of certain genes involved in proliferation and apoptosis was measured using reverse transcriptase‑polymerase chain reaction (RT‑PCR) and western blotting. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk حسب Merhi, Mahmoud

"…Moreover, a significant smoking-gene interaction is determined with CYP1A1 MspI polymorphism rs4646903 and is associated with a decreased risk of CAD in current smokers (OR 0.52137). …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications حسب Jingxuan Shan (4711089)

"…We found a highly significant association between the <b><i>CCND1</i></b><b> </b><b>rs614367-TT</b> genotype (OR = 5.14; <i>P</i> = 0.004) and TNBC risk, and identified a significant association between the <b>rs614367-T</b> allele and decreased PFS in TNBC. …"

Increasing consultant-level staffing as a proportion of overall physician coverage improves emergency department length of stay targets حسب Dominic Jenkins (9983446)

"…<h3>Objectives</h3><p dir="ltr">One goal of Emergency Department (ED) operations is achieving an overall length of stay (LOS) that is less than four hours. The goal of the current study was to assess for association between increasing number of on-duty EM Consultants and LOS, while adjusting for overall (all-grade) on-duty emergency doctors’ numbers and other operational factors.…"

Factors Affecting Environmental Knowledge and Attitudes among Lebanese College Students حسب Oweini, Ahmad

"…This exploratory study aimed at assessing the variables that would positively affect the knowledge and attitude of a group of Lebanese college students regarding the environment, namely such factors as gender, age, previous hiking experience and living abroad. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Investigation of the Effect of Imatinib and Hydroxyurea Combination Therapy on Hematological Parameters and Gene Expression in Chronic Myeloid Leukemia (CML) Patients حسب Esraa K. Al-Amleh (16023071)

"…Platelet counts, on the other hand, dramatically decreased in both IM and (HU + IM).</p><h3>Conclusion</h3><p dir="ltr">Because the studied genes (BCL2, PP2A, CIP2A, and WT1) are participating in cell proliferation and death, the findings show that the examined genes are significant to understand the efficacy of various therapies. …"

Irritable bowel syndrome: prevalence, risk factors in an adult Lebanese population حسب Chatila, Rajaa

"…The participants aged less than 30 years old were at a higher risk of having IBS (P˂ 0.01). …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Project manager perceptions factors influencing the delivery of successful innovation in construction projects حسب DIAB, MOHAMED EL SAYED

"…The main findings show that there is an influence of project manager perceptions factors on delivering successful innovation at a construction project level with evidence that his leadership, capabilities/competences, personality traits, and skills (non-engineering skills) are relatively important for the significance influence. …"
احصل على النص الكامل

Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor–induced hepatotoxicity is mediated by Kupffer cells حسب Abi-Habib, Ralph J.

"…In addition, DTU2mGMCSF, a modified form of DT390mGMCSF with enhanced tumor cell specificity, was not hepatotoxic and was significantly less toxic to KC in vivo and in vitro. …"
احصل على النص الكامل
احصل على النص الكامل

Prevalence and associated factors of DSM-5 insomnia disorder in the general population of Qatar حسب Salma Mawfek Khaled (14159013)

Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes حسب Maryam Aghadi (17128819)

"…Lack of FOXA2 resulted in significant alterations in the expression of key developmental and functional genes in hepatic progenitors (HP) and mature hepatocytes (MH) as well as an increase in the expression of ER stress markers. …"

Coronary artery disease (CAD) risk factor analysis in an age-stratified hospital population with systemic lupus erythematosus (SLE) حسب Dennis J., Levinson

"…ConclusionCAD in the young adult patient with SLE is represented predominately by an African-American population and it is dominated by a hypercoagulable state and a less significant role for diabetes. In the lupus cohort over 55 years, which is predominantly Caucasian, SLE specific factors are less significant.…"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Prevalence, Associated Risk Factors, and Adverse Cardiovascular Outcomes of Statins Discontinuation: A Systematic Review حسب Shahd A. Ageeb (22047824)

"…This review aimed to determine the prevalence of statin therapy discontinuation, its associated factors, and adverse cardiovascular outcomes within the first year of discontinuation.…"

An Investigation into the factors influencing Arabic speaking students’ proficiency in the Arabic language in Dubai British School حسب AL AHMAD, ALAAEDDIN MEHY

"…However, those Arabic-speaking students attending non-Arabic schools become less proficient in the Arabic language and continually fall behind their peers in Arabic schools. …"
احصل على النص الكامل

The assessment of cadmium, chromium, copper, and nickel tolerance and bioaccumulation by shrub plant <i>Tetraena qataranse</i> حسب Kamal Usman (11482990)

"…Cd had a translocation factor (TF) greater than one; however, it is less than one for all other metals, suggesting that the plant remediate Cd by phytoextraction, where it accumulates in the shoot and Cr, Cu and Ni through phytostabilization, concentrating the metals in the root. …"

Acute Myeloid Leukemia in Qatar (2010–2016): Clinical, Biological, and Prognostic Factors and Treatment Outcomes حسب Halima El Omri (14778790)

"…The 3-year OS and DFS were 40 and 36%, respectively. Prognostic factors including age, gender, white blood cell count, and risk stratification were not significantly associated with treatment outcomes, whereas response to treatment vs. failure was significantly associated with the outcome (<i>p</i> = 0.01). …"

Comparative study of SPI success factors in global and in-house environment for large-scale software companies حسب Javed Iqbal (2121922)

"…Still, less attention has been paid to the SPI success factors in the case of the GSD environment for large-scale software companies. …"

Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 حسب Olfa Khalifa (10914452)

"…</p> <p>Results: Treatment with 200nM Ex-4 for 3h decreased the OA-induced lipid buildup significantly (p<0.05). …"