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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Oral contraceptive pills and possible adverse effects
منشور في 2014"…Since their introduction to the market, there have been significant changes in the drug content and formulations of these products, in part to decrease the risk of adverse effects. …"
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The Impact of a Computerized Potassium Alert on Adverse Drug Events and Pharmacists' Interventions
منشور في 2010"…Conclusions: Implementation of a computerized pharmacy alert resulted in a statistically significant decrease in adverse drug events related to hyperkalemia in our institution. …"
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Efficient multi-objective neural architecture search framework via policy gradient algorithm
منشور في 2024"…Notably, compared with other multi-objective NAS methods, our NAS framework effectively decreases the computational burden (accounting for just 1/6 of the NSGA-Net). …"
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Prediction of pressure gradient for oil-water flow: A comprehensive analysis on the performance of machine learning algorithms
منشور في 2022"…<p dir="ltr">Pressure gradient (PG) in liquid-liquid flow is one of the key components to design an energy-efficient transportation system for wellbores. …"
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Fast Text Classification using Lean Gradient Descent Feed Forward Neural Network for Category Feature Augmentation
منشور في 2024"…The latter is trained using the gradient descent algorithm allowing to iteratively update the term-category matrix until reaching convergence. …"
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A hybrid model to predict the pressure gradient for the liquid-liquid flow in both horizontal and inclined pipes for unknown flow patterns
منشور في 2023"…<p dir="ltr">Accurate prediction of the pressure gradient (PG) for the oil-water flow requires identification of the flow pattern (FP), which is usually achieved by using either an expensive measurement system or time-consuming manual observations. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Hyperspectral-physiological based predictive model for transpiration in greenhouses under CO<sub>2</sub> enrichment
منشور في 2023"…The results demonstrated the inclusion of hyperspectral-based vegetation indices significantly increased the performance of the three machine learning models in predicting transpiration. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Spatial, temporal, and demographic patterns in prevalence of chewing tobacco use in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Diseas...
منشور في 2021"…Among females, none of these 12 countries had significant decreases in prevalence of chewing tobacco use, whereas seven of 12 countries had a significant decrease in the prevalence of tobacco smoking use for the period. …"