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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…</p><p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences: <a href="https://dx.doi.org/10.3389/fmolb.2022.1018464" rel="noreferrer" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.1018464</a>, published online 19 October 2022.…"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Oral contraceptive pills and possible adverse effects
منشور في 2014"…Since their introduction to the market, there have been significant changes in the drug content and formulations of these products, in part to decrease the risk of adverse effects. …"
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Effectiveness and specificity of a classroom-based group intervention in children and adolescents exposed to war in Lebanon
منشور في 2008"…The rates of disorders peaked one month post-war and decreased over one year. There was no significant effect of the intervention on the rates of MDD, SAD or PTSD. …"
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The Impact of a Computerized Potassium Alert on Adverse Drug Events and Pharmacists' Interventions
منشور في 2010"…Conclusions: Implementation of a computerized pharmacy alert resulted in a statistically significant decrease in adverse drug events related to hyperkalemia in our institution. …"
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The Impact of Cooperative Learning on Speaking Performance among University Foundation Programme Students
منشور في 2019"…The experimental group got exposed to instruction based on CL techniques while the control group was taught without being instructed to use the CL activities. …"
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Counter Revolutions via Extremists Groups. (c2016)
منشور في 2016"…The end of the year 2010 incorporated a highly significant set of events in the Middle East And North Africa (MENA) region. …"
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Feasibility of a group-based laughter yoga therapy on anxiety and happiness among community-dwelling older adults: A quasi-experimental study
منشور في 2024"…</p><p><br></p><h3>Results</h3><p dir="ltr">A statistically significant decrease in anxiety level among the study group compared to the control group (Pre = 16.68 (7.35), immediate = 6.65 (2.89), post three-month = 7.68 (2.75), p=<0.001 and effect size = 0.715). …"
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Effect of corporate ethics and social responsibility on OCB: the role of employee identification and perceived CSR significance
منشور في 2021"…Partial least square structural equation modeling (PLS-SEM) is used to analyze the data and multi-group analysis is conducted to investigate the role of perceived CSR significance. …"
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Group Relative Deprivation and Violent Radicalism: Moving Toward a Comprehensive Model
منشور في 2025"…The results also confirm that group‐based contempt is uniquely predictive of support for violence, unlike group‐based anger. …"