بدائل البحث:
significant i » significance _ (توسيع البحث)
i increases » _ increased (توسيع البحث), _ increase (توسيع البحث)
larger » large (توسيع البحث)
decrease » increase (توسيع البحث)
significant i » significance _ (توسيع البحث)
i increases » _ increased (توسيع البحث), _ increase (توسيع البحث)
larger » large (توسيع البحث)
decrease » increase (توسيع البحث)
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Photoactivatable RuII Complex Bearing 2,9‐Diphenyl‐1,10‐phenanthroline: Unusual Photochemistry and Significant Potency on Cisplatin‐Resistant Cell Lines
منشور في 2018"…Complex 1 demonstrated only marginal activity in the dark; its cytotoxicity increased significantly upon photoactivation with a high phototoxicity index (PI = [IC50 dark]/[IC50 light]) ranging from 39.2‐fold in A549 to over 100‐fold in MDA‐MB‐231. …"
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Significance of Avicennia Marina in the Arabian Gulf Environment: A Review
منشور في 2025"…<p dir="ltr">Mangroves are ecologically important and highly productive intertidal plants that thrive in saline to brackish environments in tropical and subtropical shallow-water habitats. <i>Avicennia marina</i> is the only mangrove species found in the Arabian Gulf (hereafter the ‘Gulf’) coastal region, marking the northernmost boundary of mangroves in the Indo-Pacific region. …"
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HbA1c over 8.5% is not predictive of increased infection rate following penile prosthesis implant surgery in diabetic patients with erectile dysfunction
منشور في 2021"…A comparison between diabetic patients with penile prosthesis implantation infection and those without infection revealed no significant difference in the level of haemoglobinA1c between the two groups with mean haemoglobinA1c in patients with infected implants 7.14 and 7.59 for noninfected (<i>p</i> = 0.491). …"
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Cardiac phosphodiesterases are differentially increased in diabetic cardiomyopathy
منشور في 2021"…Upregulation of β1-AR receptor transcripts was noted in diabetic hearts at 4 weeks along with an increase in cAMP levels and an upregulation in the ejection fraction and fraction shortening. …"
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Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer
منشور في 2016"…There were significant differences between the groups in postoperative histology, with an increase in pathological stage III and TRG 4–5 in the R1 group. …"
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The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR)
منشور في 2023"…Bisulfite-sequencing demonstrated 45.6% demethylation efficiency at the NY-ESO-1 gene promoter region and RT-qPCR analysis confirmed the significant induction of NY-ESO-1 at mRNA level (128-fold increase, *p < 0.050). …"
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Exploring the evolution of <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i> resistance during the COVID-19 era
منشور في 2025"…</p><h3>Results</h3><p dir="ltr">The average age of the patients was 61.3 ± 21.9 years (range: 18–95), with a majority of 1306 (51.6%) being male. During the pandemic, <i>A. baumannii</i> isolates showed a significant increase in resistance rates for several antibiotics compared to the pre-pandemic period: imipenem (96% vs 35.1%), amikacin (84.1% vs 14.4%), ciprofloxacin (96.9% vs 36.9%), trimethoprim-sulfamethoxazole (66.4% vs 27%), and ceftazidime (96.5% vs 33.3%) (all with <i>P</i>< .001). …"
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Hemodynamics of small aneurysm pairs at the internal carotid artery
منشور في 2012"…The maximum wall shear stress increases for serial aneurysms, but decreases for parallel aneurysms. …"
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The impact of different acidic conditions and food substrates on <i>Listeria </i><i>monocytogenes</i> biofilms development and removal using nanoencapsulated carvacrol
منشور في 2024"…In food substrates, nanoencapsulated carvacrol induced lower log reductions (1.58–2.90) than the ones in TSB (2.02–3.61). These findings provide valuable insights into the impact of different acidic conditions on the development of <i>L. monocytogenes</i> biofilms on stainless steel surfaces and the potential application of nanoencapsulated carvacrol as a biofilm control agent in food processing environments.…"
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Surgical Management of Hepatic Benign Disease: Have the Number of Liver Resections Increased in the Era of Minimally Invasive Approach? Analysis from the I Go MILS (Italian Group o...
منشور في 2020"…Discussion BD represents a valid indication for MILS. For BD, 21.1% of MILS was performed, rate significantly lower than that previously reported in Italy. …"
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Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1<sup>+</sup>/NKX6.1<sup>+</sup> progenitors
منشور في 2024"…Single-cell analysis revealed high RFX6 expression levels in endocrine clusters across various hESC-derived pancreatic differentiation stages. Upon differentiating iPSCs lacking RFX6 into pancreatic islets, a significant decrease in PDX1 expression at the PF stage was observed, although this did not affect PPs co-expressing PDX1 and NKX6.1. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. …"
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Downregulation of <i>CYP17A1</i> by 20-hydroxyecdysone: plasma progesterone and its vasodilatory properties
منشور في 2022"…Conclusion: In the short term, 20-hydroxyecdysone mediates CYP17A1 downregulation without a significant increase in plasma progesterone, which has a vasodilatory effect involving inhibition of voltage-dependent calcium channels, and the potential to enhance 20-hydroxyecdysone vasorelaxation.…"
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