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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Deep learning-based modeling of land use/land cover changes impact on land surface temperature in Greater Amman Municipality, Jordan (1980–2030)
منشور في 2024"…However, agricultural areas decreased from 152.13 km<sup>2</sup> (18.5%) in 1980 to 140.38 km<sup>2</sup> (17%) in 2023, while barren lands decreased from 54.44 km<sup>2</sup> (6.6%) in 1980 to 34.71 km<sup>2</sup> (4.22%) in 2023. …"
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The Impact of Non-Interest Income on Commercial Bank Profitability in the Middle East and North Africa (MENA) Region
منشور في 2024"…Non-interest income significantly influences the profitability of MENA region banks across all three models, supporting the main hypothesis. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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Investigating the Effect of Patient-Related Factors on Computed Tomography Radiation Dose Using Regression and Correlation Analysis
منشور في 2024"…Moreover, the study investigated the correlation between the different CT dose indices. Using linear regression models and Pearson correlation, the study found that all CT dose indices correlate with BMI and weight in all CT exams with varying degrees as opposed to age, which did not demonstrate any significant correlation with any of the CT dose indices across all CT exams. …"
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The Impact of Board Gender Diversity on European Firms’ Performance: The Moderating Role of Liquidity
منشور في 2024"…Furthermore, the findings indicated that leverage had a significant negative impact on profitability. Finally, both the size and GDP have a significant beneficial impact on profitability. …"
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Geospatial modelling of seasonal water and electricity consumption in Doha's residential buildings using multiscale geographically weighted regression (MGWR) and Bootstrap analysis
منشور في 2024"…The methods involved assessing the relationship between land surface temperature (LST), household water-electricity consumption, and analyzing the impact of demographic variables. Key findings indicate significant spatiotemporal variations in consumption influenced by changes in LULC and demographic characteristics such as household size and structure. …"
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The Impact of Education on Economic Growth
منشور في 2018"…This paper concentrates on the impact of education on the economic growth in the United Arab Emirates. …"
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