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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Nomograph derivation for underwater sour gas releases in shallow waters based on computational fluid dynamics simulations
منشور في 2024"…<p dir="ltr">Ruptured <u>underwater pipelines</u> releasing sour gas (i.e., natural gas with high concentrations of H<sub>2</sub>S) pose significant threats to environmental safety due to their toxic and contaminative properties. …"
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Release of colloids in saturated porous media under transient hydro-chemical conditions: A pore-scale study
منشور في 2021"…Favorable, medium-favorable and unfavorable colloids (i.e., repulsion absent, repulsion at long-range of separation distances and attraction absent with the micromodel surface, respectively) were deposited in the micromodel and then a series of colloid release experiments were conducted at different conditions including increasing the flow rate, decreasing the ionic strength and increasing the solution pH. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Impacts of COVID-19 pandemic on environment, society, and food security
منشور في 2023"…However, its negative impacts are by far critical such as increased death rate, increased release of microcontaminants (pesticides, biocides, pharmaceuticals, surfactants, polycyclic aromatic hydrocarbons (PAHs), flame retardants, and heavy metals), increased biomedical waste generation due to excessive use of safety equipment and its disposal, and municipal solid waste generation. …"
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Impact of information availability on starvation mitigation and delay minimal delivery in ICRCNs
منشور في 2014"…In this case, it was shown in [1] that the downstream source SRU may suffer from a significant starvation problem. As such, a Markov decision process framework was established therein to identify a suitable Bulk Release Decision Policy (BRDP). …"
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Recovery of electro-mechanical properties inside self-healing composites through microencapsulation of carbon nanotubes
منشور في 2020"…A small amount of CNTs inside the microcapsules is found to have no significant impact on the thermal stability of the system, as determined by thermogravimetric analysis and differential scanning calorimetry. …"
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The Impact of Nutritional Supplementation During Pregnancy on the Incidence of Gestational Diabetes and Glycaemia Control
منشور في 2022"…<div><p>The nutritional state before and throughout pregnancy has a critical impact on the women's health and the baby's development and growth. …"
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The hazardous impacts of mining activities on population's health in Blue Nile State - Sudan
منشور في 2014"…<h3 dir="ltr">Background</h3><p dir="ltr">In recent decades the Ingessana Hills, namely the Bao and Jam areas located in the Southwest of the Blue Nile State in Sudan, have been very important areas due to their mining activities. By releasing bio-monitoring systems we can facilitate extensive evaluation of environmental hazards and their impact on human health.…"
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Socio‐economic impact of solar cooking technologies on community kitchens under different climate conditions: A review
منشور في 2024"…Moreover, the payback period ranges from 3 to 6 years, contingent on the technology's cost, climatic conditions, and available subsidies. Consequently, significant positive impacts on society, the economy, and the environment are observed when traditional cooking devices are replaced by solar cooking devices. …"
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The impact of taxation, technological innovation and trade openness on renewable energy investment: Evidence from the top renewable energy producing countries
منشور في 2024"…Conversely, innovation and trade openness exhibit a positive and significant influence on clean energy investment. Regarding the moderating influence of taxation, the results revealed that tax revenues depress the positive impact exerted by technological innovation and international trade. …"
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