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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Distinct genomic features across cytolytic subgroups in skin melanoma
منشور في 2022"…SBS7a/b, SBS5 and SBS1 were the most prevalent mutational signatures across both cytolytic subgroups, but SBS1 differed significantly between them. …"
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On Time-Dependent Rheology of Sutterby Nanofluid Transport across a Rotating Cone with Anisotropic Slip Constraints and Bioconvection
منشور في 2022"…Five coupled equations with nonlinear terms are resolved numerically through the utilization of a MATLAB code for the Runge–Kutta procedure. The parameters of buoyancy ratio, the porosity of medium, and bioconvection Rayleigh number decrease x-direction velocity. …"
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Analysing Satellite Imagery Classification under Spatial Domain Shift across Geographic Regions
منشور في 2025"…<p dir="ltr">Deep learning models are designed based on the i.i.d. assumption; consequently, they experience a significant performance drop due to the distribution shifts when deployed in real environments. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Deep random vector functional link transformer network with multiple output layers for significant wave height forecasting
منشور في 2025"…The computational results demonstrate the superiority of the proposed models through a comparative analysis against state-of-the-art approaches across fifteen significant wave height time series, validated by three error metrics and a statistical test.…"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…<p dir="ltr">Hemodynamically significant patent ductus arteriosus (hsPDA) is a major cause of neonatal morbidity and mortality in extremely low birth weight (ELBW) infants. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.…"
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Exploring the Role of School Leaders in Enhancing Staff Wellbeing for School Improvement: A Case Study in a Private School in Dubai
منشور في 2023"…Staff wellbeing has been identified as a crucial factor in improving school performance and student outcomes. …"
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Nonlinear Control of Brushless Dual-Fed Induction Generator With a Flywheel Energy Storage System for Improved System Performance
منشور في 2025"…After optimization, the SMC settling time was significantly reduced from 0.7 seconds to 19.97 milliseconds, achieving a 96.9% improvement in response speed, while its steady-state error decreased from 0.48 to 0.06, marking an 87.5% reduction in tracking error. …"