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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…In this regard, engineering of brighter bioluminescent proteins, i.e. luciferases, has played a significant role. This is acutely exemplified by the engineering of the NLuc <u>luciferase</u>, which is small in size and displays much enhanced bioluminescence and<u> thermal stability</u> compared to previously available luciferases. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Comparative analysis of 5-year efficacy and outcomes of single anastomosis procedures as revisional surgery for weight regain following sleeve gastrectomy
منشور في 2023"…</p><h3>Results</h3><p dir="ltr">The study comprised 91 patients, with 42 and 49 in the SADI-S and OAGB-MGB groups, respectively. Significant weight loss (measured by total weight loss percentage, TWL%) was observed at the 5-year follow-up for the SADI-S group compared to the OAGB-MGB group (30.0 ± 18.4 vs. 19.4 ± 16.3, p = 0.008). …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A Comparative study of Technical Efficiency in GCC Islamic Financial Institutions during the Global financial Crisis using Malmquist-Type Data Envelopment analysis
منشور في 2013"…The results suggest that generally GCC and non-GCC IFIs efficiency was not significantly affected by the financial crisis. However, Individual IFIs result showed that some bank has experienced increase or decrease of efficiency after the crisis. …"
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Double versus triple arthrodesis for adult-acquired flatfoot deformity due to stage III posterior tibial tendon insufficiency: a prospective comparative study of two cohorts
منشور في 2022"…<h2>Purpose</h2> <p>The study aims to prospectively compare double and triple arthrodesis in terms of functional outcomes and deformity correction. …"
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Seventy‐year disruption of seasons characteristics in the Arabian Peninsula
منشور في 2023"…The most remarkable changes were noticed during the last 30 years. Compared to the 70-year analysis, the 1990–2019 analysis showed extra prolongation in the duration of summer and a shortage in winter, which aligns with the recent warming and drying of the Arabian Peninsula. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Impact of AREDS in a developing country 5 years after publication of the study
منشور في 2011"…Our study assesses the impact of this study on vitamin supplementation in patients with advanced AMD from 5 years before publication of the AREDS results until 5 years after. …"
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The outcome of severe traumatic brain injury in children in Qatar: Six-year study
منشور في 2015"…Finally, the incidence of TBIs from road traffic crashes and injuries in Qatar are increasing significantly compared to other developing and developed countries. …"
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Patients with early onset of type 1 diabetes have significantly higher GG genotype at position 49 of the CTLA4 gene
منشور في 2004"…Patients were nonobese and <26 years old. The CTLA4 G allele was found to be more frequently present in patients with T1D (32.4%) as compared with its frequency in control individuals (24.5%). …"
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A comparative analysis to forecast carbon dioxide emissions
منشور في 2022"…<p dir="ltr">Despite the growing knowledge and commitment to climate change, carbon dioxide (CO<sub>2</sub>) emissions continue to rise dramatically throughout the planet. In recent years, the consequences of climate change have become more catastrophic and have attracted widespread attention globally. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Epidemiology of SARS-CoV2 in Qatar’s primary care population aged 10 years and above
منشور في 2022"…It was higher in males compared to females (16.2 and 12.7% respectively). …"