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Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy
منشور في 2019"…We also found increased levels of LAMP-1 and LAMP-2A both <i>in vitro</i> and <i>in vivo</i>, along with decreased levels of α-synuclein. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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HOW TO PROMOTE MEDIATION OF CONSTRUCTION DISPUTES IN THE UAE
منشور في 2020"…In the last twenty years, development has been made to dispute resolution methods to come up with a set of recognized alternatives apart from litigation, and it is made available now to the contracting parties. Mediation is one of the most recognized alternative dispute resolution methods, which has developed significantly and been adopted by many countries with mature economics, such as Malaysia and the UK, etc. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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The mediating effect of Work Engagement on the relation between Career Adaptability and OCB
منشور في 2020"…Results indicated that career adaptability has significant positive influence on OCB and work engagement, work engagement in turn is positively associated with OCB and acted as a partial mediator for career adaptability and OCB. …"
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masterThesis -
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Family resources, resilience beliefs, and parental adaptation: A moderated mediation analysis
منشور في 2024"…There was no evidence that family relationships and marital satisfaction mediated the association between stressor pile‐up and parent stress. …"
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Molecular Mechanisms of Adiponectin-Induced Attenuation of Mechanical Stretch-Mediated Vascular Remodeling
منشور في 2020"…Stretching the RPV also significantly increased ROS generation after 1 hour, whereas APN significantly decreased mechanical stretch-induced ROS production. …"
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Media exposure,mediated social comparison to idealized images of muscularity, and anabolic steroid use
منشور في 2014"…This study examined the association between anabolic–androgenic steroid (AAS) use and dominant sociocultural factors, specifically media exposure to idealized images of male muscularity, and mediated social comparison trends among a sample of young Arab adults. …"
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The mediating effect of organisational resilience and internal preparedness on the relationship between external vulnerabilities and performance
منشور في 2024"…The relationships between resilient characteristics, resilient capacities, and firm performance were also positive and significant. The mediation results showed an indirect relationship between resilient characteristics and firm performance, and resilient capacities fully mediated this association. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Waterpipe Tobacco Smoke Nicotine Mediates Resilience to Chronic Stress by Activating BDNF Signaling
منشور في 2020"…Even though initially, WTS decreased anxiety-like behaviors it was found that prolonged exposure after the completion of CSDS significantly induced anxiety-like behaviors. …"
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masterThesis