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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Efficacy of lower arch leveling, lower incisors’ root resorption, and pain associated with the correction of curve of Spee using different orthodontic archwires: a randomized clini...
منشور في 2022"…<h3>Objectives</h3> <p>To compare between 3 archwires (AWs) for leveling curve of Spee (COS) in terms of efficacy of reduction, external apical root resorption (EARR), pain experienced, and the lower arch dimensional changes during COS leveling.…"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Highway geometric design changes in response to a fully autonomous vehicle fleet. (c2018)
منشور في 2018"…Stopping Sight Distance (SSD), Decision Sight Distance (DSD), and length of sag and crest vertical curves are geometric design elements directly affected by the inevitable change. …"
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masterThesis -
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Impacts of climate change on the global spread and habitat suitability of <i>Coxiella burnetii</i>: Future projections and public health implications
منشور في 2025"…Climate variables were obtained from five global circulation models (GCMs) under two climate change scenarios (SSP2-4.5 and SSP5-8.5). The study evaluated the models’ performance using the area under the curve (AUC) and true skill statistics (TSS). …"
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Does trade openness mitigate environmental degradation in Organisation for Economic Co‐operation and Development (OECD) countries? Implications for achieving sustainable developmen...
منشور في 2024"…These divergent effects support the environmental Kuznets curve hypothesis. Our findings suggest that as income levels rise, the indirect effect gradually outweighs the direct effect, leading to a significant reduction in long‐term CO<sub>2</sub> emissions in OECD countries.…"
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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo
منشور في 2017"…A significant decrease in protein levels of p53 and Bcl-2 and a significant increase in p21 and Bax were observed. …"
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Renewable Energy, Coal as a Baseload Power Source, and Greenhouse Gas Emissions: Evidence from U.S. State-Level Data
منشور في 2017"…It is estimated that a 10% increase in the share of renewable energy could decrease CH4 emissions by about 0.26%. …"
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Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma
منشور في 2020"…However, only in lower dose of sumac were significant decreases in the expression of oncogenic miR210 and increase of tumor-suppressive miR145 (miR21, miR22, and miR155 were not changed) observed. …"
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The Effect of Recombinant Anthrax Lethal Toxin on Breast Cancer Cell Motility, Adhesion, and Invasion
منشور في 2020"…Additionally, cells treated with LT showed an increase in adhesion, decrease in invasion across a collagen matrix, and in increase in Rho A activation. …"
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masterThesis