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Detection of statistically significant network changes in complex biological networks
منشور في 2017"…The ability to detect statistical relevant changes in the interaction patterns induced by the progression of the disease can lead to the discovery of novel relevant signatures. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Identifying and Assessing the Significance of Digital Twin Enablers in the Construction Industry
منشور في 2025احصل على النص الكامل
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…This is specifically relevant in designing assays that require bioluminescence for extended periods, such as in the case of biosensors designed for monitoring slow enzymatic or <u>cellular signaling</u> reactions, without necessitating multiple rounds of luciferase substrate addition or any specialized reagents that result in increased assay costs. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Conceptual Skills in Leading Change: A Competence Approach to Public Sector Leadership
منشور في 2019"…The thesis concludes on the significance of individuals’ conceptual skills in leading public sector change by presenting a framework of conceptual skills relevant to four areas of leadership: self-regulation, sensemaking, integrative leadership and innovative leadership. …"
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Project Managers’ Competencies in Managing the People Elements of Change within the United Arab Emirates
منشور في 2017"…The study also found that managing change projects competencies (MP1, MP2, MP3, MP5 and MP9) is significantly associated with achieving PM objectives. …"
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Organizational Change Management: A study on the need for a re-structured organization within a functional configuration
منشور في 2009"…The objective of this study was to qualitatively examine the current organizational structure and systematically investigate and review proposed changes at an Oil Refining Organization. In this study a critical investigation will be conducted to mainly identify and recommend relevant dimensions of a new organizational structure and offer some tentative recommendations to the optimal approach in a project organizational selection context in order to help the current organization overcome cuncurrent organizational difficulties pertaining to managing projects. …"
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Assessing the Built Environment’s Reflectivity, Flexibility, Resourcefulness, and Rapidity Resilience Qualities against Climate Change Impacts from the Perspective of Different Sta...
منشور في 2023"…<p dir="ltr">The frequency and severity of climate change are projected to increase, leading to more disasters, increased built environment system (BES) vulnerability, and decreased coping capacity. …"
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Positional and dimensional temporomandibular joint osseous changes in patients treated with the forsus fatigue resistant device: a non-randomized clinical trial
منشور في 2025"…In the treatment group, condylar width decreased significantly by 0.52 ± 0.92 mm, in contrast to an increase of 0.17 ± 0.35 mm in the control group (<i>P</i> = 0.010). …"
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Claims Management and Substantiation in the United Arab Emirates Construction Sector
منشور في 2012"…Some of the findings revealed in this dissertation were the importance of records keeping, formal notifications and significance of change and change orders in the context of claims management and other key aspects relevant to the field of claims management and substantiation.…"
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