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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Long-Chain Acyl-CoA Synthetase 1 Role in Sepsis and Immunity: Perspectives From a Parallel Review of Public Transcriptome Datasets and of the Literature
منشور في 2019"…Furthermore, available clinical data indicate that levels of ACSL1 and ACSL4 induction was significantly higher in fatal cases of sepsis. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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A Clinically Interpretable Approach for Early Detection of Autism Using Machine Learning With Explainable AI
منشور في 2025"…The novelty of this work lies in the integration of explainable AI with robust preprocessing and age-specific modeling across multiple ASD datasets, addressing both diagnostic accuracy and clinical interpretability. …"
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Improving clinical documentation: automatic inference of ICD-10 codes from patient notes using BERT model
منشور في 2023"…Electronic health records provide a vast amount of text health data written by physicians as patient clinical notes. The world health organization released the international classification of diseases version 10 (ICD-10) system to monitor and analyze clinical notes. …"
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Annexin A3 in sepsis: novel perspectives from an exploration of public transcriptome data
منشور في 2020"…<p dir="ltr">According to publicly available transcriptome datasets, the abundance of Annexin A3 (ANXA3) is robustly increased during the course of sepsis; however, no studies have examined the biological significance or clinical relevance of ANXA3 in this pathology. …"
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Applications of artificial intelligence in ultrasound imaging for carpal-tunnel syndrome diagnosis: a scoping review
منشور في 2025"…Editorials, expert opinions, conference papers, dataset publications, and studies that did not have a clear clinical application of the AI algorithm were excluded.…"
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Implementation of Deep Learning for Measurement of Penile Curvature on Real 2D Intraoperative Images
منشور في 2025"…Only 6% of cases crossed the 30° surgical threshold, confirming the tool’s reliability for clinical decision-making. </p><h3 dir="ltr">Discussion</h3><p dir="ltr">This study demonstrates the successful implementation of deep learning and keypoint-based measurement of PC that could significantly improve patient assessment by surgeons and hypospadiology researchers.…"