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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…<p dir="ltr">Coronavirus Disease of 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a massive health crisis across the globe, with some genetic variants gaining enhanced infectivity and competitive fitness, and thus significantly aggravating the global health concern. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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A comparative analysis to forecast carbon dioxide emissions
منشور في 2022"…The root mean square error (RMSE), mean absolute error (MAE) and mean absolute percentage error (MAPE) are used to analyze and compare the performances of the predictive models. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Evaluating chemiluminescent immunoassays for syphilis detection: A comparative analysis
منشور في 2025"…BackgroundSyphilis, caused by Treponema pallidum (TP), remains a significant global public health concern, with approximately 8 million new cases annually. …"
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An Investigation of the Development and Implementation of Teacher's Licensing in Saudi Arabia Based on Local Stakeholders' Perceptions, Compared to International and Regional Pract...
منشور في 2023"…However, promoting teacher quality concerns leaders in the education sector, and significant efforts to raise teacher quality are paramount to government leaders. …"
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Green Supply Chains: A Comparative Efficiency Analysis in the Gulf and Beyond
منشور في 2023"…We based our empirical analysis on UN SDGs concerned with clean energy, innovation, sustainable communities, and climate action (SDGs 7, 9, 11, and 13, respectively). …"
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Deep and transfer learning for building occupancy detection: A review and comparative analysis
منشور في 2022"…Typically, analyzing big occupancy data gathered by BIoT networks helps significantly identify the causes of wasted energy and recommend corrective actions. …"
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Neutralizing antibodies against SARS-CoV-2 are higher but decline faster in mRNA vaccinees compared to individuals with natural infection
منشور في 2022"…Unlike the VN group, the NI group mounted a lasting anti-S1-IgA response with no significant decline. Anti-S1-IgA, which were ~ 3-fold higher in VN subjects compared with NI in P-1 (<i>P</i> < 0.001), dropped to almost the same levels, with no significant difference observed between the two groups in P-II.…"
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Comparative analysis of metaheuristic load balancing algorithms for efficient load balancing in cloud computing
منشور في 2023"…The primary objective of load balancing is to map workloads to use computing resources that significantly improve performance. Load balancing in cloud computing falls under the class of concerns defined as "NP-hard" issues due to vast solution space. …"
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Comparative assessment of fracture risk among osteoporosis and osteopenia patients: a cross-sectional study
منشور في 2018"…</p><h3>Results: </h3><p dir="ltr">Patients with osteoporosis had significantly higher risk of major fracture compared to patients with osteopenia (p<0.01). …"