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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Distinct genomic features across cytolytic subgroups in skin melanoma
منشور في 2022"…SBS7a/b, SBS5 and SBS1 were the most prevalent mutational signatures across both cytolytic subgroups, but SBS1 differed significantly between them. SBS7a/b was mutually exclusive with SBS5 and SBS1 in both CYT subgroups. …"
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A Novel Steganography Technique for Digital Images Using the Least Significant Bit Substitution Method
منشور في 2022"…Therefore, the proposed work, in this paper, is based on the Least Significant Bit (LSB) substitution method. The LSB substitution method can minimize the error rate in embedding process and can achieve greater reliability in criteria, using novel algorithm based on value difference. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Understanding dispute resolution in the Middle East region from perspectives of different stakeholders
منشور في 2016"…The responses were analyzed from three distinct perspectives, namely contractors, owners, and claim advisors. …"
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Executing Sharia court decisions in the dissolution of marriages between Jerusalemites with different identity cards: implications for the Israeli settler colonial project
منشور في 2025"…<p dir="ltr">While significant scholarly attention has focused on the Israeli state’s efforts to control Palestinian intimate lives, a notable gap remains regarding the legal mechanisms, particularly the fragmented legal systems impacting Palestinian women in marriages involving holders of different identity cards in East Jerusalem and the broader political and ideological objectives of Israeli settler-colonialism. …"
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Altered regulation of cell migration in IRF6-mutated orofacial cleft patients-derived primary cells reveals a novel role of RhoGTPases in cleft/lip palate development
منشور في 2021"…The aim is to look for significant differences in the behaviour of the CL/P patient-derived cells in vitro when compared to control cells from the healthy donor through the study of different mechanisms, including cell proliferation, cell migration and adhesion. …"
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Comparative Metagenomics of Cedar Forest Soils in Lebanon: Uncovering Microbial Diversity and Ecological Patterns
منشور في 2025"…Beta diversity analysis using principal coordinate analysis (PcoA) further confirmed the significant difference in microbial composition between forests, with Tannourine’s samples grouped to the right forming a well-separated cluster, while other forests showed distinct shifts, likely due to local environmental factors. …"
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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo
منشور في 2017"…A significant decrease in protein levels of p53 and Bcl-2 and a significant increase in p21 and Bax were observed. …"
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Immunoprofile of childhood diabetes
منشور في 2023"…Despite having distinctly different pathologies, both types of diabetes are associated with defects in immune regulation that mediate sensitivity to insulin. …"