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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Transforming Dermatopathology With AI: Addressing Bias, Enhancing Interpretability, and Shaping Future Diagnostics
منشور في 2025"…Inclusive frameworks, such as the Monk scale, and advanced segmentation methods effectively address dataset biases. However, challenges such as the “black box” nature of AI, ethical concerns about data privacy, and limited access to advanced technologies in low‐resource settings remain.…"
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Addressing Language Errors in L2 Students' Writing: Can Corpora Help?
منشور في 2011احصل على النص الكامل
doctoralThesis -
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Deep random vector functional link transformer network with multiple output layers for significant wave height forecasting
منشور في 2025"…This paper introduces a novel random vector functional link transformer (RFT) and ensemble deep random vector functional link transformer (edRFT) networks to capture the dynamic characteristics of significant wave heights. The model employs hidden blocks based on transformer encoders to effectively capture complex sequential dependencies in the data. …"
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The significance of general skills training for early career graduates: relationships with perceived organizational support, job satisfaction and turnover intention
منشور في 2023"…Importantly, JS only has an effect on turnover intention when in the presence of serial mediation by POS. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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احصل على النص الكامل
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Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation
منشور في 2025"…The pharmacokinetic analysis of 2a and assessment of its in vivo efficacy in addressing hepatic impairment in rat models of diabetes and pre-diabetes were carried out. …"
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احصل على النص الكامل
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Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation
منشور في 2025"…The pharmacokinetic analysis of <b>2a</b> and assessment of its in vivo efficacy in addressing hepatic impairment in rat models of diabetes and pre-diabetes were carried out. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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The Impact of Staff Engagement Towards the Institutional Quality Assurance Processes of Higher Education Institutions in the UAE
منشور في 2025"…Additionally, the analysis revealed a significant gap between the institutional policies and staff engagement, underlining the need for specific approaches to address this issue. …"
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The effect of utilizing danielson framework for teaching on teachers' perceptions of effective teaching. (c2019)
منشور في 2019"…The goal of this study was to address such issues by examining teachers’ perceptions of effective teaching behaviors and qualities before and after implementing the Danielson Framework for Teaching at a school in Beirut. …"
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احصل على النص الكامل
masterThesis -
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