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Factors Influencing the Magnitude and Clinical Significance of Drug Interactions Between Azole Antifungals and Select Immunosuppressants
منشور في 2006"…The magnitude of drug interactions between azole antifungals and immunosuppressants is drug and patient specific and depends on the potency of the azole inhibitor involved, the resulting plasma concentrations of each drug, the drug formulation, and interpatient variability. Many factors contribute to variability in the magnitude and clinical significance of drug interactions between an immunosuppressant such as cyclosporine, tacrolimus, or sirolimus and an antifungal agent such as ketoconazole, fluconazole, itraconazole, voriconazole, or posaconazole. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Significance of microscopically incomplete resection margin after esophagectomy for esophageal cancer
منشور في 2016"…Propensity score matching and multivariable analyses were used to compensate for differences in baseline characteristics. Results: Independent factors significantly associated with an R1 resection margin included an upper third esophageal tumor location, preoperative malnutrition, and pathological stage III. …"
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Invasive Plants Diversity, Ecological Status, and Distribution Pattern in Relation to Edaphic Factors in Different Habitat Types of District Mandi Bahauddin, Punjab, Pakistan
منشور في 2022"…Ordination analysis showed that different ecological factors had a significant (p ≤ 0.002) influence on vegetation. …"
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Gender differences in personal values
منشور في 2015"…Findings – The findings show that females place a higher weight on personal values related to the broad categories of “ethics” and “citizenship”, while males put a stronger emphasis on “masculinity”. There were no significant differences between males and females on personal values concerned with the “vision” factor. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Seismic response modification, over-strength, and displacement amplification factors of steel special truss moment frames
منشور في 2023"…The results show that the number of stories and the different special segment lengths affect the seismic parameters significantly. …"
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The Development And Significance Of Business Intelligence (BI) Platforms In Facilitating The Decision-Making Process In Dubai Government Entities
منشور في 2022"…Using secondary research design, the study determined factors that impact the decision-making process in Dubai government entities. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Human factors frameworks in analysis of contributory factors to medication error: A systematic review
منشور في 2025"…Human factor (HF) frameworks address this by providing a comprehensive and systematic methodology for analysing these factors. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Organizational factors that influence the success of IT projects
منشور في 2018"…Overall, the study could measure project success of IT projects through organizational factors. The reliable differences of sample data have determined that the organizational factors have a significant relationship in measuring project success.…"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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An Exploration of Critical Success Factors of Virtual Distributed Projects
منشور في 2016"…This has assisted in acquiring various facts about the significance of virtually distributed projects. Along with the same, different advantages that leaders working in the organization can have through virtual team has been worked out specifically. …"
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