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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Population Reference Values for Serum Methylmalonic Acid Concentrations and Its Relationship with Age, Sex, Race-Ethnicity, Supplement Use, Kidney Function and Serum Vitamin B12 in...
منشور في 2018"…Population reference values for serum MMA concentrations in post-folic acid fortification period are lacking. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Variation of Shear Wave Velocity with SPT-N Values in the City of Sharjah
منشور في 2014احصل على النص الكامل
doctoralThesis -
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Functionalized Metal Organic Frameworks For Chemotherapy Drug Delivery
منشور في 2020احصل على النص الكامل
doctoralThesis -
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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احصل على النص الكامل
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Fermentation-induced modifications to the structural, surface, and functional properties of quinoa proteins
منشور في 2025"…Notably, fermentation significantly increases the digestibility of QPs from 78.13 to 85.24%, thereby enhancing their nutritional value. …"
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Ensemble Deep Random Vector Functional Link Neural Network for Regression
منشور في 2022"…Subsequently, we propose a novel regularization method [boosted factor (BF)], two dRVFLs variants [edRVFL with skip connection (edRVFL-SC) and edRVFL with random skip connections (edRVFL-RSC)] and one strategy [ensemble skip connection edRVFL (esc-edRVFL)] which show significant improvement over the original dRVFL. The BF is a newly introduced hyperparameter to scale the values of the activated hidden neurons to accommodate the diversity of the data, and it is also able to filter the neurons. edRVFL-SC and edRVFL-RSC are the edRVFL variants with skip connections. …"
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Functional Connectivity Analysis under Vigilance Decrement and Enhanced Mental States
منشور في 2020احصل على النص الكامل
doctoralThesis -
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Effectiveness of Project Management Office (PMO) in UAE Context: Exploring the Link between Meeting the Critical Success Factors (CSFs) of Central Enterprise PMO and its Added Valu...
منشور في 2013"…One of the most significant current discussions in the project management field is having an effective PMO that can play significant roles to enable organizations to achieve their goals and objectives through enhancing the effectiveness of the project management, hence Meeting the CSFs of the central EPMOs is a crucial factor to ensure that central EPMOs add the expected values to their organizations. …"
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