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Genome‐wide DNA methylation analysis of colorectal adenomas with and without recurrence reveals an association between cytosine‐phosphate‐guanine methylation and histological subty...
منشور في 2019"…Unsupervised hierarchical clustering exhibited a significant association of methylation patterns with histological adenoma subtypes. …"
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Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status
منشور في 2021"…This study aims to characterize PDB-associated changes in DNA methylation profiles in patients’ blood. Meta-analysis of data from the discovery and cross-validation set, each comprising 116 PDB cases and 130 controls, revealed significant differences in DNA methylation at 14 CpG sites, 4 CpG islands, and 6 gene-body regions. …"
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Parametric Study of Methyl Orange Removal Using Metal–Organic Frameworks Based on Factorial Experimental Design Analysis
منشور في 2022"…The statistical analysis demonstrated that the MOF type was the most significant factor, followed by dosage and initial concentration. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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The Use of the Gene Expression Omnibus (GEO) Database to Study Gene Expression and Methylation Patterns in Cases of Preterm Birth and Associated Diseases
منشور في 2023"…<h3>Objective</h3> <p>Analysis of gene expression and methylation patterns in preterm births (PTB) and associated diseases from microarray data using the Gene Expression Omnibus (GEO) database. …"
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DNA methylation signatures in Blood DNA of Hutchinson–Gilford Progeria syndrome
منشور في 2022"…We could observe DNA methylation alterations at 61 CpG sites as well as 32 significant regions following a 5 Kb tiling analysis. …"
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Epigenetic DNA Methylation Signatures Associated With the Severity of Paget’s Disease of Bone
منشور في 2022"…</p><p><br></p><h3>Results: </h3><p dir="ltr">We identified 100 CpG methylation sites significantly associated with PDB severity at FDR <0.05. …"
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Accelerated epigenetic aging and DNA methylation alterations in Berardinelli–Seip congenital lipodystrophy
منشور في 2023"…We also observed a shortened lifespan of Caenorhabditis elegans following knockdown of the BSCL2 homolog seip-1 on a daf-16/forkhead box, class O mutant background. DNA methylation analysis revealed significant differentially methylated sites enriched for lyase activity, kinase regulator activity, protein kinase regulator activity and kinase activator activity. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Methylomic profiling in trisomy 21 identifies cognition- and Alzheimer’s disease-related dysregulation
منشور في 2019"…Performing a targeted association analysis for the significant T21-associated CpG sites in the AgeCoDe cohort, we found that 9 showed significant methylation differences related to AD dementia, including one in the ADAM10 gene. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Ribosomal DNA Copy Number Variation is Coupled with DNA Methylation Changes at the 45S rDNA Locus
منشور في 2023"…Furthermore, we did not observe any significant alterations in rDNA CN or DNA methylation in Autism Spectrum Disorder (ASD) brains in 16 ASD vs 11 control samples. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Integrated epigenome, whole genome sequence and metabolome analyses identify novel multi-omics pathways in type 2 diabetes: a Middle Eastern study
منشور في 2023"…Methylome-metabolome analysis identified 66 significant CpG-metabolite pairs among which 61 pairs were novel. …"