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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Coexistence of negative and positive polarity electrostatic solitary waves in ultradense relativistic negative-ion-beam permeated plasmas
منشور في 2018"…It is shown that the coexistence of positive and negative potential pulses occurs in a certain interval of parameter values, where the ion beam inertia becomes significant.…"
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Diagnostic accuracy of interleukin-6 (IL-6) as a significant biomarker in late-onset neonatal sepsis: an updated systematic review and meta-analysis
منشور في 2025"…What is New:• This meta-analysis used a bivariate model to estimate IL-6 performance, yielding high pooled sensitivity (85.2%) and specificity (84.1%).…"
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Bacteriuria in pregnancy varies with the ambiance: a retrospective observational study at a tertiary hospital in Doha, Qatar
منشور في 2023"…</p> <h3>Results</h3> <p>Of the 21.24% positive cultures, 11.25% had SB. SB showed a significant strong positive (r = +0.677, n = 17, P = 0.003) and moderate negative (r = −0.587, n = 17, P = 0.013) correlation with average monthly temperature and humidity, respectively, with doubling of rates noted with temperatures ≥35°C (11.3% vs. 3.6%; P < 0.0001) and humidity ≤50% (10.6% vs. 3.2%; P < 0.0001). …"
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POSITIVE AND NEGATIVE POLITENESS IN EGYPTIAN AND AMERICAN MEDIA DISCOURSE (A CONTRASTIVE STUDY)
منشور في 2017"…A contrastive analysis of both spoken Egyptian Arabic and spoken American English was done. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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ExoventQ: A Novel Low-Cost Portable Negative Pressure Ventilator Design and Implementation
منشور في 2024"…<p dir="ltr">The emergence of COVID-19 resulted in significant shortages of mechanical ventilators globally. …"
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The significance of general skills training for early career graduates: relationships with perceived organizational support, job satisfaction and turnover intention
منشور في 2023"…Findings– The main finding is that participation in general skills training (PGST) does not directly impact turnover intention, rather POS is a mechanism through which this negative relationship operates. This study also found significant evidence for serial mediation by POS on PGST and its relationship with turnover intention. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Illegitimate Tasks, Negative Affectivity, and Organizational Citizenship Behavior among Private School Teachers: AMediated–Moderated Model
منشور في 2024"…Results demonstrate the effects of illegitimate tasks on OCB are indirect and statistically significant and are mediated through negative affectivity. …"
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Transcriptional alterations of protein coding and noncoding RNAs in triple negative breast cancer in response to DNA methyltransferases inhibition
منشور في 2021"…Concordantly, DNMT inhibition led to significant inhibition of TNBC cell proliferation, G2-M cell cycle arrest and induction of cell death. …"
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Liposomal delivery of DK14 chalcone analogue: A promising therapeutic strategy against triple-negative breast cancer
منشور في 2025"…<p>Triple negative breast cancer (TNBC) is considered the most aggressive type of breast malignancy. …"