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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Effect of corporate ethics and social responsibility on OCB: the role of employee identification and perceived CSR significance
منشور في 2021"…Based on a framework involving the resource-based view of the firm and the social identity theory, the CSR-OCB relationship is investigated with regard to employees’ perceived significance of CSR practices as well as their identification (association level) with the organization. …"
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The Spectrum of Mutations of Homocystinuria in the MENA Region
منشور في 2020"…This review aims to examine the mutations spectrum of the CBS gene, the disease management, as well as the current and potential treatment approaches with a greater emphasis on studies reported in the Middle East and North Africa (MENA) region.…"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Gestational Diabetes in the Gulf Region: Streamlining care to optimise outcome
منشور في 2015"…The options for minimising variations in screening and diagnosis and new opportunities for streamlining care across the Gulf region are explored. This proposition has the potential for driving an enabling environment for sharing best practices as well as engaging in collaborative research across the GCC.…"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Land use and limitations in the sinkhole and polje karst of the Ksiromero Region, Western Greece
منشور في 2013"…Shallow groundwater occurs in some of these reservoirs, as well as seasonally captured storm water, but much is pumped in from the adjacent region or from nearby wells. …"
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Autocleandeepfood: auto-cleaning and data balancing transfer learning for regional gastronomy food computing
منشور في 2024"…Nevertheless, obtaining high-quality, well-labeled, and well-balanced real-world labeled images is challenging since manual data curation requires significant human effort and is time-consuming. …"
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A novel approach on the delineation of a multipurpose energy-greenbelt to produce biofuel and combat desertification in arid regions
منشور في 2022"…Meanwhile, a few approaches on the delineation of greenbelts to fight desertification in the arid regions exist in literature. This study presents a novel approach to delineate a multipurpose energy-greenbelt using JCL crop for biofuel production, as well as to preserve the soil and enhance air quality, thereby helping to combat desertification and sand-dust storms (SDS). …"
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R<sup>2</sup>S100K: Road-Region Segmentation Dataset for Semi-supervised Autonomous Driving in the Wild
منشور في 2024"…However, existing autonomous driving datasets provide well-structured urban roads while ignoring unstructured roadways containing distress, potholes, water puddles, and various kinds of road patches i.e., earthen, gravel etc. …"