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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Demand Forecasting in Supply Chain Management for Rossmann Stores Using Weather Enhanced Deep Learning Model
منشور في 2024"…The proposed approach GRU with Grid search showed better performances as compared to previously suggested Long Short Term Memory (LSTM) model. Moreover, Gated Recurrent Unit (GRU) with Grid Search showed significant improvement in sales demand forecasting accuracy when considering weather-related data subsets. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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An innovative simulated annealing approach to the long-term hydroscheduling problem
منشور في 2001"…This paper presents a new simulated annealing algorithm (SAA) to solve the long-term hydro scheduling problem (LTHSP). A new algorithm for randomly generating feasible trial solutions is introduced. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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A long-lived cuprous bis-phenanthroline complex for the photodynamic therapy of cancer
منشور في 2018"…The DNA breaks were significantly amplified upon photoactivation. The light-induced enhancement of cytotoxicity was associated with the formation of reactive oxygen species (ROS), a known intermediate in photodynamic therapy (PDT). …"
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Swimming exercise improves short‐ and long‐term memories: Time‐course changes
منشور في 2021"…On the other hand, swimming exercise-induced significant enhancement to the learning phase and memory formation after 7 days of training (p < 0.01). …"
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A new tabu search algorithm for the long-term hydro scheduling problem
منشور في 2002"…A new efficient algorithm to solve the long-term hydro scheduling problem (LTHSP) is presented in this paper. …"
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Anomaly Detection on Smart Grids With Optimized Convolutional Long Short-Term Memory Model
منشور في 2025"…The results indicate that the proposed model provides a robust solution for improving the security and reliability of smart grids, and it offers significant benefits to utility providers who seek to mitigate energy theft and enhance grid resilience.…"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Nanomaterials in fire protection: Innovations for enhanced safety and durability
منشور في 2025"…Nanomaterials offer enhanced efficiency, long-term durability, and reduced environmental impact compared to traditional flame retardants. …"