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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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PFDI: a precise fruit disease identification model based on context data fusion with faster-CNN in edge computing environment
منشور في 2023"…<div><p>Fruits significantly impact everyday living, i.e., Citrus fruits. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Novel platinum II and platinum IV complexes exhibit potent cytotoxicity and selectivity towards several cancer cell lines
منشور في 2020"…Evaluation of apoptotic proteins’ expression was performed using western blots. Results showed that both complexes significantly reduced cancer cell viability and exhibited 7 to 20-fold higher cytotoxicity compared to cisplatin. …"
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masterThesis -
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The anti-neoplastic activity of novel platinum II and IV complexes against A549 lung cancer cells
منشور في 2021"…Cellular uptake of both drugs using the ICP-MS revealed that both drugs use active transport, with AK1 having a faster and higher uptake than AK2. …"
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masterThesis -
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Cyberbullying Detection in Arabic Text using Deep Learning
منشور في 2023"…In the new era of digital communications, cyberbullying is a significant concern for society. Cyberbullying involves the use of communication technology and data, including messages, photographs, and videos, to undertake aggressive negative actions to harm others. …"
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Multimodal EEG and Keystroke Dynamics Based Biometric System Using Machine Learning Algorithms
منشور في 2021"…These results outperform the individual modalities with a significant margin (~5%). We also developed a binary template matching-based algorithm, which gives 93.64% accuracy 6X faster. …"
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Simulating the thermal behavior of buildings using artificial neural networks-based coarse-grain modeling
منشور في 2004"…The main advantages of the approach compared to conventional simulation methods are (1) simplified model construction for the end-user; (2) simplified model reconfiguration; (3) significantly faster simulation runs (orders of magnitude faster for two- and three-dimensional models); and (4) potentially more accurate results. …"
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Accurate prediction of dynamic viscosity of polyalpha-olefin boron nitride nanofluids using machine learning
منشور في 2023"…These results suggest that the use of machine learning models can significantly improve the accuracy of predicting the viscosity of PAO-hBN nanofluids. …"
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Pore-scale simulation of fine particles migration in porous media using coupled CFD-DEM
منشور في 2022"…The time required to develop bridging and subsequent clogging of the pore space that lead to permeability reduction decreases as the flow velocity increases. The size of the fine particles has a significant impact on permeability reduction where the reduction in permeability increases as the size of particles increases. …"
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Forward simulation of three-dimensional advection-diffusion using a fundamental solution for a linear flow
منشور في 2022"…In a regime where the patch does not grow too much in size, the results of our algorithm, which is significantly faster, show acceptable agreement with COMSOL.…"
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masterThesis