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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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Sex differences in shoulder performance fatiguability are affected by arm position, dominance and muscle group
منشور في 2022"…There was a significant difference between the ER and IR muscles, with significantly higher values observed for the IR in C.Perf (mean difference = 331.74 J) by 30.0% and in BR (mean difference = 13.31 J) by 26.64%. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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Differences in Player Position Running Velocity at Lactate Thresholds Among Male Professional German Soccer Players
منشور في 2019"…In addition, the largest difference between positions for running velocity was found at the lactate threshold v2 (p = 0.005). …"
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Effect of consanguinity on birth weight for gestational age in a developing country
منشور في 2007"…No significant difference was observed in the decrease in birth weight between the first- and second-cousin marriages. …"
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Effects of habitat complexity on the abundance, species richness and size of darkling beetles (Tenebrionidae) in artificial vegetation
منشور في 2016"…Increasing complexity appeared to lead to decreasing beetle widths. 9 beetle species were relatively rare in, or absent from, the higher complexity treatments, including 5 of the 6 largest species. 2 rare, small beetle species were only found in higher complexity treatments. …"
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β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo
منشور في 2017"…A significant decrease in protein levels of p53 and Bcl-2 and a significant increase in p21 and Bax were observed. …"
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Face-To-Face, Blended, Hybrid, and Online Instructional Delivery Methods: a Comparative Study of English Language Learners’ Grades in a Mathematics Course in a Higher Education Ins...
منشور في 2020"…Furthermore, this study used Cohen’s d and Hedges’ g for the pairwise comparisons of the six statistically significant results. The results revealed that (a) students scored statistically significantly lower grades in the face‑to‑face group than in the blended group with a mean difference of 0.72 and an effect size of .47, (b) students in the face‑to‑face group scored statistically significantly lower than the students in the hybrid group, with a mean difference of 1.17 and an effect size of .79, (c) the face‑to‑face group displayed the largest statistically significant mean difference of 2.23 lower than the online group, with a very large effect size of 1.49, which was also the greatest effect size of the study, (d) students scored statistically significantly lower grades in the in the blended group than hybrid group, with a mean different of .45 and an effect size of 0.31, (e) students in the blended group scored lower grades than in the online delivery, with a mean difference of 1.51 and an effect size of 1.05, and (f) the hybrid group scored statistically significantly lower than the online group with a mean difference of 1.06 and an effect size of 0.87. …"
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Renewable Energy, Coal as a Baseload Power Source, and Greenhouse Gas Emissions: Evidence from U.S. State-Level Data
منشور في 2017"…It is estimated that a 10% increase in the share of renewable energy could decrease CH4 emissions by about 0.26%. …"
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Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma
منشور في 2020"…However, only in lower dose of sumac were significant decreases in the expression of oncogenic miR210 and increase of tumor-suppressive miR145 (miR21, miR22, and miR155 were not changed) observed. …"
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The Effect of Recombinant Anthrax Lethal Toxin on Breast Cancer Cell Motility, Adhesion, and Invasion
منشور في 2020"…Additionally, cells treated with LT showed an increase in adhesion, decrease in invasion across a collagen matrix, and in increase in Rho A activation. …"
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masterThesis