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Increased Frequency of Severe Hypoglycemia with the Modified-Release Gliclazide Compared to Glimepiride in Diabetic Older Adults; Propensity Score-Adjusted Analysis
منشور في 2022"…<h3>Objective</h3><p dir="ltr">The main aim is to compare the risk of severe hypoglycemia associated with the modified-release (MR) gliclazide against glimepiride in diabetic older adults. …"
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Ultrasound Triggered Release of Estrone- Targeted Liposomes
منشور في 2017احصل على النص الكامل
doctoralThesis -
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Investigating the acoustic release of doxorubicin from targeted micelles
منشور في 2013"…We applied low frequency ultrasound as an external stimulus and measured the amount of release of Dox from these folated micelles. The results showed that the percent drug release increases as the power intensity of ultrasound increases. …"
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Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles
منشور في 2001"…Above this threshold, the amount of release was shown to increase as the pulse length increased up to 0.6 s. …"
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Ultrasound triggered release of Trastuzumab-conjugated immunoliposomes targeting breast cancer
منشور في 2018احصل على النص الكامل
doctoralThesis -
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Ultrasound-responsive Nanocarriers in Cancer Treatment: a review
منشور في 2021"…Using smart nanocarriers, the rate of release of the entrapped therapeutic(s) can be increased, and greater exposure of the tumor cells to the therapeutics can be achieved when the nanocarriers are exposed to certain internally (enzymes, pH and temperature) or externally applied (light, magnetic field, and ultrasound) stimuli that trigger the release of their load in a safe and controlled manner, spatially and temporally. …"
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Acoustically activated release of estrone-targeted liposomes used for breast cancer treatment
منشور في 2016احصل على النص الكامل
doctoralThesis -
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Lacertus fibrosus release in proximal median nerve entrapment- a systematic review
منشور في 2025"…A significant proportion of the patients had a history of unsuccessful conservative or surgical management (prior carpal tunnel release in 10.5%). …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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Accelerated dissolution testing for controlled release microspheres using the flow-through dissolution apparatus
منشور في 2008"…The effect of increased temperature was determined to be the statistically significant variable.…"
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احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Release of colloids in saturated porous media under transient hydro-chemical conditions: A pore-scale study
منشور في 2021"…<p dir="ltr">The deposition and consequent release of colloids pose a significant challenge to the environment, groundwater quality and human health. …"