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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Breast cancer screening in Lebanon: Understanding knowledge, attitudes and barriers
منشور في 2024"…Education significantly affected BC knowledge. Interestingly, increased knowledge of BC reduced barriers to mammographic screening. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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A Multi-Channel Convolutional Neural Network approach to automate the citation screening process
منشور في 2021"…<p dir="ltr">The systematic literature review (SLR) process is separated into several steps to increase rigor and reproducibility. The selection of primary studies (i.e., citation screening) is an important step in the SLR process. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…In this regard, the recent SARS-CoV-2 alpha, beta, and gamma variants (B.1.1.7, B.1.351, and P.1 lineages, respectively) are of great significance in that they contain several mutations that increase their transmission rates as evident from clinical reports. …"
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Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion
منشور في 2014"…Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. …"
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A screening instrument for sleep apnea predicts airway maneuvers in patients undergoing advanced endoscopic procedures
منشور في 2010"…AMs and hypoxemia occur at an increased frequency in these patients.…"
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Screen Time Soars and Vision Suffers: How School Closures During the Pandemic Affected Children and Adolescents’ Eyesight
منشور في 2024"…School closures in Qatar were associated with a significant increase in screen time among students and a notable decline in their visual acuity. …"
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Prevalence and clinical significance of antiphospholipid antibodies in patients with coronavirus disease 2019 admitted to intensive care units: a prospective observational study
منشور في 2022"…<p>Coronavirus disease 2019 (COVID-19) increases the risk of coagulopathy. Although the presence of antiphospholipid antibodies (aPLs) has been proposed as a possible mechanism of COVID-19-induced coagulopathy, its clinical significance remains uncertain. …"
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Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells
منشور في 2014"…The increase in apoptosis in response to treatment was also apparent in the increase in BAX and the decrease in Bcl-2 levels as well as the proteolytic cleavage of both caspase-3 and PARP as revealed by Western blot. …"
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A lipidomic screen of hyperglycemia-treated HRECs links 12/15-Lipoxygenase to microvascular dysfunction during diabetic retinopathy via NADPH oxidase
منشور في 2015"…Here, we investigated the role of bioactive lipid metabolites, in particular 12/15-lipoxygenase (LOX)-derived metabolites, in this process. LC/MS lipidomic screen of human retinal endothelial cells (HRECs) demonstrated that 15-HETE was the only significantly increased metabolite (2.4 ± 0.4-fold, <i>P</i> = 0.0004) by high glucose (30 mM) treatment. …"
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Students Plugged: The Psychological Impact of Smart Devices Screen Time Exposure on Cognitive Concentration Skills in Primary School Students in Abu Dhabi
منشور في 2025"…Increased engagement with entertainment and gaming content was linked to lower cognitive scores; in other words, screen time correlated with diminished cognitive concentration. …"
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Colon Cancer General Knowledge, Attitude and Awareness Channels: A Cross‐Sectional Study
منشور في 2025"…Awareness of colon cancer and its screening tools has a fundamental role in increasing screening participation. …"
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