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Drivers obesity and road crash risks in the United States
منشور في 2015"…<p dir="ltr">We assessed obesity trends in US drivers involved in fatal crashes since 1999 and distinguished whether crash risk factors were different between obese and non-obese drivers. …"
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GIS-based spatiotemporal analysis for road traffic crashes; in support of sustainable transportation Planning
منشور في 2023"…Road traffic crashes pose a significant challenge worldwide, necessitating increased efforts to reduce them and promote sustainable transport systems. …"
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GIS-based spatiotemporal analysis for road traffic crashes; in support of sustainable transportation Planning
منشور في 2023"…<p>Road traffic crashes pose a significant challenge worldwide, necessitating increased efforts to reduce them and promote sustainable transport systems. …"
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The development of psychological and associated mental health disorders after road traffic crashes and other injuries
منشور في 2015"…<p dir="ltr">Injury contributes approximately 12% of the world’s burden of injury and there is increasing evidence that injury results in the new onset of a range of psychiatric disorders. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …"
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
منشور في 2022"…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …"
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
منشور في 2019"…Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …"
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
منشور في 2025"…While a low Mg content (5 %) only slightly impacted the print quality and dimensions, higher Mg concentrations (10 % and 15 %) led to increased weight, rougher surfaces, dimensional shrinkage in height, and overall poorer formation quality. Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …"
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The Anti-Tumor Agent Sodium Selenate Decreases Methylated PP2A, Increases GSK3βY216 Phosphorylation, Including Tau Disease Epitopes and Reduces Neuronal Excitability in SHSY-5Y Neu...
منشور في 2019"…Somewhat surprisingly, the catalytically active form, methylated PP2A (mePP2A) was significantly decreased. In close correlation to these data, the phosphorylation state of two substrate proteins, sensitive to PP2A activity, GSK3β and Tau were found to be increased. …"
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment
منشور في 2023"…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. In our practice, we administer one or two courses of ibuprofen followed by a single course of indomethacin if the PDA has not shown closure or decrease in size on the echocardiogram (echo) exam. …"
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Quasi-static axial crushing investigation of filament-wound eco-friendly energy-absorbing glass fiber and jute fiber composite structures
منشور في 2024"…Both JF and GF 2-layer configurations showed less progressive failure due to their lightweight nature, with crush force efficiency (CFE) of 0.44–0.46 and specific energy absorption (SEA) of 4.4–5.1 J/g, raising considerations for crash scenarios involving human safety. The 4-layer JF configuration demonstrated a significant increase in IPF to 3496 N, effectively restricting buckling and brittle fracture and leading to a higher SEA of 12.61 J/g. …"
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The Effect of HuArgI (Co)-PEG5000 on The Migration of Ovarian Cancer
منشور في 2020"…HuArgI (Co)-PEG5000 is a potential drug to target cancers that depend on exogenous sources of arginine and cannot synthesize their own. In this study, we hypothesized that HuArgI (Co)- PEG5000 can decrease the migration of ovarian cancer cells. …"
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Effect of the stretch rate during uniaxial testing on the mechanical properties of prolene
منشور في 2017"…We assess the effects of stretch rate on the mechanical properties of Prolene® (Ethicon, Gynecare, Somerville, NJ, USA), a knitted polypropylene mesh. …"
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Board changes and CEO turnover
منشور في 2014"…For firms that decrease independence, the CEO turnover performance sensitivity significantly decreases following SOX. …"
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Optical pavement treatments and their impact on speed and lateral position at transition zones: A driving simulator study
منشور في 2021"…Previous studies have highlighted that crash rates are usually higher in these sections. …"